ArticleJournal of structural biology2012
Cryo-electron tomography and 3-D analysis of the intact flagellum in Trypanosoma brucei.
Article in Journal of structural biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Review
- Isotropic reconstruction for electron tomography with deep learning.Nature communications · 2022Article
- Structure, function and druggability of the African trypanosome flagellum.Journal of cellular physiology · 2022Review
- PCD Genes-From Patients to Model Organisms and Back to Humans.International journal of molecular sciences · 2022Review
- Expansion microscopy facilitates quantitative super-resolution studies of cytoskeletal structures in kinetoplastid parasites.Open biology · 2021Article
- Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells.Cell discovery · 2021Article
- Article
- Article
- African trypanosomes.Parasites & vectors · 2019Article
- Motile Cilia: Innovation and Insight From Ciliate Model Organisms.Frontiers in cell and developmental biology · 2019Review
- Dependency relationships between IFT-dependent flagellum elongation and cell morphogenesis inOpen biology · 2018Article
- Flagellum couples cell shape to motility inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- A lumenal interrupted helix in human sperm tail microtubules.Scientific reports · 2018Article
- Cryo-electron tomography: an ideal method to study membrane-associated proteins.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Giant FAZ10 is required for flagellum attachment zone stabilization and furrow positioning inJournal of cell science · 2017Article
- Flagellar pocket restructuring through the Leishmania life cycle involves a discrete flagellum attachment zone.Journal of cell science · 2016Article
- 3D Architecture of the Trypanosoma brucei Flagella Connector, a Mobile Transmembrane Junction.PLoS neglected tropical diseases · 2016Article
- Review
- A dynamic coordination of flagellum and cytoplasmic cytoskeleton assembly specifies cell morphogenesis in trypanosomes.Journal of cell science · 2015Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Trypanosoma brucei is a uni-cellular protist that causes African sleeping sickness. These parasites have a flagellum that is attached to the cell body and is indispensible for its motility. The flagellum consists of a canonical 9+2 axoneme and a paraflagellar rod (PFR), an intricate tripartite, fibrous structure that is connected to the axoneme. In this paper we describe results from cryo-electron tomography of unperturbed flagella. This method revealed novel structures that are likely involved in attaching the flagellum to the cell. We also show the first cryo-electron tomographic images of a basal body in situ, revealing electron dense structures inside its triplet microtubules. Sub-tomogram averaging of the PFR revealed that its distal region is organized as an orthorhombic crystal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.