ArticleBioorganic & medicinal chemistry2012
Tannic acid inhibited norovirus binding to HBGA receptors, a study of 50 Chinese medicinal herbs.
Article in Bioorganic & medicinal chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Combined use of dill essential oil and tannic acid creates stage-specific, and time-dependent antiviral effect against bovine viral pathogens (BoHV-1, BVDV, BPIV-3, BRSV, and BEV).Veterinary research communications · 2026Article
- The anti-coronaviral activity of singular and mixed formulation of dill essential oil (Anethum graveolens L.) and tannic acid (Quercus infectoria).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Tannic Acid and Ethacridine Lactate Attenuate Markers of Stress-Induced Intestinal Barrier Dysfunctions in Murine Small Intestinal Organoids.Biomolecules · 2025Article
- Antiviral Activity of Natural Compounds for Food Safety.Food and environmental virology · 2024Review
- A Reappraisal of the Antiviral Properties of and Immune Regulation through Dietary Phytochemicals.ACS pharmacology & translational science · 2023Review
- Antiviral functionalization of cellulose using tannic acid and tannin-rich extracts.Frontiers in microbiology · 2023Article
- Natural extracts, honey, and propolis as human norovirus inhibitors.Scientific reports · 2022Article
- Fucoidan But Not 2'-Fucosyllactose Inhibits Human Norovirus Replication in Zebrafish Larvae.Viruses · 2021Article
- On the Use of Persian Gum for the Development of Antiviral Edible Coatings against Murine Norovirus of Interest in Blueberries.Polymers · 2021Article
- Article
- Biological Function of Plant Tannin and Its Application in Animal Health.Frontiers in veterinary science · 2021Review
- Tannic Acid with Antiviral and Antibacterial Activity as A Promising Component of Biomaterials-A Minireview.Materials (Basel, Switzerland) · 2020Review
- Technological Application of Tannin-Based Extracts.Molecules (Basel, Switzerland) · 2020Review
- Natural bioactive substances for the control of food-borne viruses and contaminants in food.Food production, processing and nutrition · 2020Review
- Article
- Specific Interactions between Human Norovirus and Environmental Matrices: Effects on the Virus Ecology.Viruses · 2019Review
- Monomeric catechin and dimeric procyanidin B2 against human norovirus surrogates and their physicochemical interactions.Food microbiology · 2018Article
- Antiviral Activity of Tannic Acid Modified Silver Nanoparticles: Potential to Activate Immune Response in Herpes Genitalis.Viruses · 2018Article
- Potential and challenges of tannins as an alternative to in-feed antibiotics for farm animal production.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2018Review
- Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future.Current drug metabolism · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Noroviruses (NoVs) are the leading cause of viral acute gastroenteritis affecting people of all ages worldwide. The disease is difficult to control due to its widespread nature and lack of an antiviral or vaccine. NoV infection relies on the interaction of the viruses with histo-blood group antigens (HBGAs) as host receptors. Here we investigated inhibition effects of Chinese medicinal herbs against NoVs binding to HBGAs for potential antivirals against NoVs. Blocking assays was performed using the NoV protrusion (P) protein as NoV surrogate and saliva as HBGAs. Among 50 clinically effective Chinese medicinal herbs against gastroenteritis diseases, two herbs were found highly effective. Chinese Gall blocked NoV P dimer binding to type A saliva at IC(50)=5.35 μg/ml and to B saliva at IC(50)=21.7 μg/ml. Similarly, Pomegranate blocked binding of NoV P dimer to type A saliva at IC(50)=15.59 μg/ml and B saliva at IC(50)=66.67 μg/ml. Literature data on preliminary biochemistry analysis showed that tannic acid is a common composition in the extracts of the two herbs, so we speculate that it might be the effective compound and further studies using commercially available, highly purified tannic acid confirmed the tannic acid as a strong inhibitor in the binding of NoV P protein to both A and B saliva (IC(50)≈0.1 μM). In addition, we tested different forms of hydrolysable tannins with different alkyl esters, including gallic acid, ethyl gallate, lauryl gallate, octyl gallate and propyl gallate. However, none of these tannins-derivatives revealed detectable inhibiting activities. Our data suggested that tannic acid is a promising candidate antiviral against NoVs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.