ArticleMechanisms of development
CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans.
Article in Mechanisms of development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Apoptosis promotes fertility in Caenorhabditis elegans by maintaining functional germline morphology.Development (Cambridge, England) · 2026Article
- A switch in collagen expression regulates cessation of distal tip cell migration inbioRxiv : the preprint server for biology · 2025Article
- Biallelic loss-of-function variants in the splicing regulator NSRP1 cause a severe neurodevelopmental disorder with spastic cerebral palsy and epilepsy.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Article
- Inactivation of theAutophagy · 2021Article
- Invading, Leading and Navigating Cells inGenetics · 2018Review
- Regulating distal tip cell migration in space and time.Mechanisms of development · 2017Review
- RNF121 Inhibits Angiogenic Growth Factor Signaling by Restricting Cell Surface Expression of VEGFR-2.Traffic (Copenhagen, Denmark) · 2016Article
- The Effect of In Vitro Cultivation on the Transcriptome of Adult Brugia malayi.PLoS neglected tropical diseases · 2016Article
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3 authors at 1 institution in 1 country.
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Abstract
The Caenorhabditis elegans distal tip cells (DTCs) are an in vivo model for the study of developmentally regulated cell migration. In this study, we characterize a novel role for CCDC-55, a conserved coiled-coil domain containing protein, in DTC migration and larval development in C. elegans. Although animals homozygous for a probable null allele, ccdc-55(ok2851), display an early larval arrest, RNAi depletion experiments allow the analysis of later phenotypes and suggest that CCDC-55 is needed within the DTC for migration to cease at the end of larval morphogenesis. The ccdc-55 gene is found in an operon with rnf-121 and rnf-5, E3 ubiquitin ligases that target cell migration genes such as the β-integrin PAT-3. Genetic interaction studies using RNAi depletion and the deletion alleles rnf-121(ok848) and rnf-5(tm794) indicate that CCDC-55 and the RNF genes act at least partially in parallel to promote termination of cell migration in the adult DTC.
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