ArticlePhysiology & behavior2012
Selective breeding for endurance running capacity affects cognitive but not motor learning in rats.
Article in Physiology & behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Divergence in aerobic capacity and energy expenditure influence metabolic tissue mitochondrial protein synthesis rates in aged rats.GeroScience · 2024Article
- Selective breeding for physical inactivity produces cognitive deficitsFrontiers in aging neuroscience · 2023Article
- Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan.NPJ aging and mechanisms of disease · 2021Article
- Intrinsic Aerobic Capacity Affects Hippocampal pAkt and HSP72 Response to an Acute High Fat Diet and Heat Treatment in Rats.Journal of Alzheimer's disease reports · 2021Article
- Adult Hippocampal Neurogenesis and Affective Disorders: New Neurons for Psychic Well-Being.Frontiers in neuroscience · 2021Review
- Effects of exercise on proactive interference in memory: potential neuroplasticity and neurochemical mechanisms.Psychopharmacology · 2020Review
- Physical Activity and Brain Health.Genes · 2019Review
- Theoretical and Biological Evaluation of the Link between Low Exercise Capacity and Disease Risk.Cold Spring Harbor perspectives in medicine · 2018Review
- Rodent models for resolving extremes of exercise and health.Physiological genomics · 2016Review
- Differential modulation of motor cortex plasticity in skill- and endurance-trained athletes.European journal of applied physiology · 2015Article
- Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity.Annals of clinical and translational neurology · 2014Article
- Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats.Brain research bulletin · 2014Article
- Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome.Anesthesiology · 2013Article
- Linking brains and brawn: exercise and the evolution of human neurobiology.Proceedings. Biological sciences · 2013Review
- Article
- A rat model system to study complex disease risks, fitness, aging, and longevity.Trends in cardiovascular medicine · 2012Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The ability to utilize oxygen has been shown to affect a wide variety of physiological factors often considered beneficial for survival. As the ability to learn can be seen as one of the core factors of survival in mammals, we studied whether selective breeding for endurance running, an indication of aerobic capacity, also has an effect on learning. Rats selectively bred over 23 generations for their ability to perform forced treadmill running were trained in an appetitively motivated discrimination-reversal classical conditioning task, an alternating T-maze task followed by a rule change (from a shift-win to stay-win rule) and motor learning task. In the discrimination-reversal and T-maze tasks, the high-capacity runner (HCR) rats outperformed the low-capacity runner (LCR) rats, most notably in the phases requiring flexible cognition. In the Rotarod (motor-learning) task, the HCR animals were overall more agile but learned at a similar rate with the LCR group as a function of training. We conclude that the intrinsic ability to utilize oxygen is associated especially with tasks requiring plasticity of the brain structures implicated in flexible cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.