Evidence map›Paper›PMID 22284921›Full record

ArticleThe Journal of pediatrics2012

Windows of lead exposure sensitivity, attained height, and body mass index at 48 months.

Myriam Afeiche, Karen E Peterson, Brisa N Sánchez, Lourdes Schnaas, David Cantonwine, Adrienne S Ettinger, Maritsa Solano-González, Mauricio Hernández-Avila, Howard Hu, Martha M Téllez-Rojo

Abstract readComparative Study
In one paragraph

Article in The Journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 41 citations in OpenAlex.

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  17. Differential association of lead on length by zinc status in two-year old Mexican children.Environmental health : a global access science source · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Myriam AfeicheDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Karen E Peterson
Brisa N Sánchez
Lourdes Schnaas
David Cantonwine
Adrienne S Ettinger
Maritsa Solano-González
Mauricio Hernández-Avila
Howard Hu
Martha M Téllez-Rojo
University of Michigan–Ann Arbor · USNational Institute of Public Health · SIBrigham and Women's Hospital · USHarvard University · USInstituto Nacional de Perinatología · MX

Funding

Biostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AMY J SCHULZ · 2011 to 2026
$21.3M
VANADIUM AND HUMAN HEALTHP42ES005947 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 1992 to 2006
$19.6M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
Superfund Metal Mixtures, Biomarkers and NeurodevelopmentP42ES016454 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BELLINGER, DAVID C · 2010 to 2015
$10.1M
TRAINING GRANT IN ACADEMIC NUTRITIONT32DK007703 · NIDDK · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTOPHER P DUGGAN, Frank B Hu · 1994 to 2026
$7.8M
LEAD DOSE BIOMARKERS, REPRODUCTION, AND INFANT OUTCOMESR01ES007821 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, KAREN EILEEN · 1998 to 2010
$4.7M
Metals, Nutrition and Stress in Child DevelopmentP01ES012874 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI BRAIN, JOSEPH D · 2004 to 2008
$3.2M
Metal Mixtures and NeurodevelopmentR01ES014930 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROBERT O · 2006 to 2010
$3.2M
NEUROCHEMICAL AND GENETIC MARKERS OF LEAD TOXICITYK23ES000381 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROBERT O · 2000 to 2004
$670k
Project 1: Prenatal Lead Exposure, Early Childhood Growth, and Sexual MaturationP20ES018171 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, KAREN EILEEN · 2010 to 2012
$584k
NIDDK NIH HHS T32 DK007703NIEHS NIH HHS K23 ES000381NIEHS NIH HHS K23ES000381NIEHS NIH HHS P01 ES012874NIEHS NIH HHS P20 ES018171NIEHS NIH HHS P20 ES018171/RD834800NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P30ES017885NIEHS NIH HHS P42 ES005947NIEHS NIH HHS P42 ES016454NIEHS NIH HHS P42 ES05947NIEHS NIH HHS R01 ES007821NIEHS NIH HHS R01ES007821NIEHS NIH HHS R01 ES013744NIEHS NIH HHS R01 ES014930NIEHS NIH HHS R01ES014930NIEHS NIH HHS T32 ES007018
6 · The paper itself

Abstract

objectiveTo examine longitudinal associations of prenatal, infancy, and early childhood lead exposure during sensitive periods with height and body mass index (BMI). STUDY

designA total of 773 participants were recruited between 1994 and 2005 in Mexico City. Lead exposure history categories were constructed for the prenatal period (maternal patellar lead concentration) and for infancy and childhood (mean child blood lead concentration at birth to 24 months and 30-48 months, respectively). Linear regression models were used to study lead exposure history with height and BMI at 48 months.

resultsMean height at age 48 months was significantly lower in children with a blood lead level exceeding the median during infancy (-0.84 cm; 95% CI, -1.42 to -0.25) than in children with a level below the median. Prenatal lead exposure was not associated with height at 48 months. Results for attained BMI generally trended in the same direction as for height.

conclusionOur findings suggest an effect of lead exposure early in life on height attainment at 48 months, with the exposure window of greatest sensitivity in infancy.

Indexed as

Body Mass IndexBody HeightChild DevelopmentChild, PreschoolEnvironmental ExposureEnvironmental IllnessFemaleFollow-Up StudiesHumansIncidenceInfantInfant, NewbornLeadLead PoisoningMaleMexicoLead

Identifiers

PMID22284921
PMCPMC3360798
OpenAlexW2103198894

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.