ArticleAmerican journal of human genetics2012
The Arabian cradle: mitochondrial relicts of the first steps along the southern route out of Africa.
Article in American journal of human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neandertal demise: an archaeological analysis of the modern human superiority complex.PloS one · 2014Pooled it
- West Eurasian mtDNA lineages in India: an insight into the spread of the Dravidian language and the origins of the caste system.Human genetics · 2015Trial
- Intensive post-war migrations and mtDNA variation based on Poland case.Scientific reports · 2025Article
- The origin of modern North Africans as depicted by a massive survey of mitogenomes.Scientific reports · 2025Article
- Article
- Patterns of population structure and genetic variation within the Saudi Arabian population.bioRxiv : the preprint server for biology · 2025Article
- Human migration from the Levant and Arabia into Yemen since Last Glacial Maximum.Scientific reports · 2024Article
- Genetic Analysis of Mingrelians Reveals Long-Term Continuity of Populations in Western Georgia (Caucasus).Genome biology and evolution · 2023Article
- Article
- Review
- Phylogeographic history of mitochondrial haplogroup J in Scandinavia.American journal of biological anthropology · 2023Article
- Characterization of Arabian Peninsula whole exomes: Contributing to the catalogue of human diversity.iScience · 2022Article
- Article
- Uniparental markers reveal new insights on subcontinental ancestry and sex-biased admixture in Brazil.Molecular genetics and genomics : MGG · 2022Article
- Exploring the Effects of Mitonuclear Interactions on Mitochondrial DNA Gene Expression in Humans.Frontiers in genetics · 2022Article
- Projecting Ancient Ancestry in Modern-Day Arabians and Iranians: A Key Role of the Past Exposed Arabo-Persian Gulf on Human Migrations.Genome biology and evolution · 2021Article
- Genome-scale sequencing and analysis of human, wolf, and bison DNA from 25,000-year-old sediment.Current biology : CB · 2021Article
- Population structure of indigenous inhabitants of Arabia.PLoS genetics · 2021Article
- Delineation of Mitochondrial DNA Variants From Exome Sequencing Data and Association of Haplogroups With Obesity in Kuwait.Frontiers in genetics · 2021Article
- Mitochondrial genome diversity on the Central Siberian Plateau with particular reference to the prehistory of northernmost Eurasia.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major unanswered question regarding the dispersal of modern humans around the world concerns the geographical site of the first human steps outside of Africa. The "southern coastal route" model predicts that the early stages of the dispersal took place when people crossed the Red Sea to southern Arabia, but genetic evidence has hitherto been tenuous. We have addressed this question by analyzing the three minor west-Eurasian haplogroups, N1, N2, and X. These lineages branch directly from the first non-African founder node, the root of haplogroup N, and coalesce to the time of the first successful movement of modern humans out of Africa, ∼60 thousand years (ka) ago. We sequenced complete mtDNA genomes from 85 Southwest Asian samples carrying these haplogroups and compared them with a database of 300 European examples. The results show that these minor haplogroups have a relict distribution that suggests an ancient ancestry within the Arabian Peninsula, and they most likely spread from the Gulf Oasis region toward the Near East and Europe during the pluvial period 55-24 ka ago. This pattern suggests that Arabia was indeed the first staging post in the spread of modern humans around the world.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.