ArticleSurgery2012
Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition.
Article in Surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- HSA-curcumin nanoparticles: a promising substitution for Curcumin as a Cancer chemoprevention and therapy.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020Article
- Saponin from Tupistra chinensis Bak Inhibits NF-κB Signaling in Sarcoma S-180 Cell Mouse Xenografts.Current medical science · 2018Article
- Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma.Oncotarget · 2017Article
- Dendrosomal nanocurcumin and p53 overexpression synergistically trigger apoptosis in glioblastoma cells.Iranian journal of basic medical sciences · 2016Article
- Cell Proliferation in Neuroblastoma.Cancers · 2016Review
- Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells.BMC cancer · 2014Article
- Thermally responsive nanoparticle-encapsulated curcumin and its combination with mild hyperthermia for enhanced cancer cell destruction.Acta biomaterialia · 2014Article
- Nanotechnology-applied curcumin for different diseases therapy.BioMed research international · 2014Review
- Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells.International journal of nanomedicine · 2014Article
- Cell survival signaling in neuroblastoma.Anti-cancer agents in medicinal chemistry · 2013Review
- Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activity.American journal of surgery · 2013Article
- Preparation of cefquinome sulfate proliposome and its pharmacokinetics in rabbit.Iranian journal of pharmaceutical research : IJPR · 2013Article
Corrections and comments
- Retraction · 2016-02-01Falsification/Fabrication of Image · Investigation by Company/Institution ·
- Retracted
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNuclear factor-κB (NF-κB) has been implicated in tumor cell proliferation and survival and in tumor angiogenesis. We sought to evaluate the effects of curcumin, an inhibitor of NF-κB, on a xenograft model of disseminated neuroblastoma.
methodsFor in vitro studies, neuroblastoma cell lines NB1691, CHLA-20, and SK-N-AS were treated with various doses of liposomal curcumin. Disseminated neuroblastoma was established in vivo by tail vein injection of NB1691-luc cells into SCID mice, which were then treated with 50 mg/kg/day of liposomal curcumin 5 days/week intraperitoneally.
resultsCurcumin suppressed NF-κB activation and proliferation of all neuroblastoma cell lines in vitro. In vivo, curcumin treatment resulted in a significant decrease in disseminated tumor burden. Curcumin-treated tumors had decreased NF-κB activity and an associated significant decrease in tumor cell proliferation and an increase in tumor cell apoptosis, as well as a decrease in tumor vascular endothelial growth factor levels and microvessel density.
conclusionLiposomal curcumin suppressed neuroblastoma growth, with treated tumors showing a decrease in NF-κB activity. Our results suggest that liposomal curcumin may be a viable option for the treatment of neuroblastoma that works via inhibiting the NF-κB pathway.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.