Trial reportAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2012
Longitudinal progression trajectory of GFR among patients with CKD.
Trial report in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
173 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Evaluation of N-acetyl-β-D-glucosaminidase as a prognostic marker for diabetic nephropathy in type 2 diabetics: systematic review and meta-analysis.International urology and nephrology · 2024Pooled it
- Efficacy of probiotics/synbiotics supplementation in patients with chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2024Pooled it
- Pooled it
- Past Decline Versus Current eGFR and Subsequent ESRD Risk.Journal of the American Society of Nephrology : JASN · 2016Pooled it
- Effectiveness, cost effectiveness, acceptability and implementation barriers/enablers of chronic kidney disease management programs for Indigenous people in Australia, New Zealand and Canada: a systematic review of mixed evidence.BMC health services research · 2016Pooled it
- Stage 5-CKD under nephrology care: to dialyze or not to dialyze, that is the question.Journal of nephrology · 2016Pooled it
- Genome-wide association study of kidney function decline in individuals of European descent.Kidney international · 2015Pooled it
- Regression methods for investigating risk factors of chronic kidney disease outcomes: the state of the art.BMC nephrology · 2014Pooled it
- Patterns of Kidney Function Decline in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis From the HALT-PKD Trials.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2018Trial
- Acute kidney injury increases the risk of end-stage renal disease after cardiac surgery in an Asian population: a prospective cohort study.BMC nephrology · 2017Trial
- Effects of lowering LDL cholesterol on progression of kidney disease.Journal of the American Society of Nephrology : JASN · 2014Trial
- KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease): design and methods.BMC nephrology · 2014Trial
- Comparative effectiveness of early versus conventional timing of dialysis initiation in advanced CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2014Trial
- Patient perspectives on informed decision-making surrounding dialysis initiation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2013Trial
- Association of BP variability with mortality among African Americans with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2013Trial
- Length of Follow-Up Time Needed for Stable eGFR Slope Estimation in Glomerular Disease.Kidney360 · 2026Article
- The Impact of Non-AKI eGFR Variability on CKD Progression in Individuals With Type 2 Diabetes and Preserved Kidney Function.Kidney international reports · 2026Article
- Heat-KilledJournal of microbiology and biotechnology · 2026Article
- Semiparametric Joint Modeling for Survival Analysis with Longitudinal Covariates.Journal of the American Statistical Association · 2026Article
- Real-World Outcomes of Sodium-Glucose Cotransporter 2 Inhibitor Therapy in Nondiabetic Autosomal-Dominant Polycystic Kidney Disease: Effects on Progression to Dialysis in a TrinetX Cohort.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026Article
113 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe traditional paradigm of glomerular filtration rate (GFR) progression in patients with chronic kidney disease (CKD) is a steady nearly linear decline over time. We describe individual GFR progression trajectories over 12 years of follow-up in participants in the African American Study of Kidney Disease and Hypertension (AASK). STUDY
designLongitudinal observational study. SETTING &
participants846 AASK patients with at least 3 years of follow-up and 8 GFR estimates. MEASUREMENTS: Longitudinal GFR estimates from creatinine-based equations. PREDICTORS: Patient demographic and clinical features. OUTCOMES: Probability of a nonlinear trajectory and probability of a period of nonprogression calculated for each patient from a Bayesian model of individual estimated GFR (eGFR) trajectories.
results352 (41.6%) patients showed a > 0.9 probability of having either a nonlinear trajectory or a prolonged nonprogression period; in 559 (66.1%), the probability was > 0.5. Baseline eGFR > 40 mL/min/1.73 m2 and urine protein-creatinine ratio < 0.22 g/g were associated with a higher likelihood of a nonprogression period. 74 patients (8.7%) had both a substantial period of stable or increasing eGFR and a substantial period of rapid eGFR decrease. LIMITATIONS: Clinical trial population; absence of direct GFR measurements.
conclusionsIn contrast to the traditional paradigm of steady GFR progression over time, many patients with CKD have a nonlinear GFR trajectory or a prolonged period of nonprogression. These findings highlight the possibility that stable kidney disease progression can accelerate and, conversely, provide hope that CKD need not be relentlessly progressive. These results should encourage researchers to identify time-dependent factors associated with periods of nonprogression and other desirable trajectories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.