Trial reportJournal of affective disorders2012
Do sub-syndromal manic symptoms influence outcome in treatment resistant depression in adolescents? A latent class analysis from the TORDIA study.
Trial report in Journal of affective disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT00018902 (Treatment of SSRI-Resistant Depression in Adolescents), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of SSRI-Resistant Depression in Adolescents (TORDIA)
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- A systematic review of interventions for treatment resistant major depressive disorder in adolescents.European child & adolescent psychiatry · 2020Pooled it
- Trajectories of Symptom Change in School-Based Prevention Programs for Adolescent Girls with Subclinical Depression.Journal of youth and adolescence · 2022Trial
- Trajectories of Symptom Change in the Treatment for Adolescents With Depression Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Trial
- The bi-directional relationship between parent-child conflict and treatment outcome in treatment-resistant adolescent depression.Journal of the American Academy of Child and Adolescent Psychiatry · 2013Trial
- Trajectories of adolescent alcohol use after brief treatment in an Emergency Department.Drug and alcohol dependence · 2012Trial
- Differences in Reward and Punishment Sensitivity among Adolescents with Depression Varying in Manic Symptoms.Research on child and adolescent psychopathology · 2025Article
- Sex differences in pediatric major depressive episodes: a cross-sectional study on psychiatric symptoms in early-onset mood disorders.Frontiers in psychiatry · 2025Article
- Major challenges in youth psychopathology: treatment-resistant depression. A narrative review.Frontiers in psychiatry · 2024Review
- Impact of different interventions on preventing suicide and suicide attempt among children and adolescents in the United States: a microsimulation model study.Frontiers in psychiatry · 2023Article
- Predictors, Moderators, and Mediators Associated With Treatment Outcome in Randomized Clinical Trials Among Adolescents With Depression: A Scoping Review.JAMA network open · 2022Article
- Latent Class Analysis of Adolescent Psychosocial Functioning and Course of Major Depression.Research on child and adolescent psychopathology · 2021Article
- Annual Research Review: Defining and treating pediatric treatment-resistant depression.Journal of child psychology and psychiatry, and allied disciplines · 2020Review
- Trajectories of change in symptom distress in a clinical group of late adolescents: The role of maladaptive personality traits and relations with parents.Personality and mental health · 2018Article
- Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management.Current problems in pediatric and adolescent health care · 2018Review
- Characteristics of depression among offspring at high and low familial risk of bipolar disorder.Bipolar disorders · 2017Article
- Distinguishing Bipolar Depression from Unipolar Depression in Youth: Preliminary Findings.Journal of child and adolescent psychopharmacology · 2017Article
- Increased Serum Levels of Oxytocin in 'Treatment Resistant Depression in Adolescents (TRDIA)' Group.PloS one · 2016Article
- Treatment response in relation to subthreshold bipolarity in patients with major depressive disorder receiving antidepressant monotherapy: a post hoc data analysis (KOMDD study).Neuropsychiatric disease and treatment · 2016Article
- Antidepressant tolerability in anxious and depressed youth at high risk for bipolar disorder: a prospective naturalistic treatment study.Bipolar disorders · 2014Article
- Bipolar disorder in children and adolescents.Child and adolescent mental health · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundTo identify distinct depressive symptom trajectories in the TORDIA study and determine their correlates.
methodsLatent Class Growth Analysis (LCGA) using the Children's Depression Rating Scale-Revised (CDRS-R) through 72 weeks from intake.
results3 classes were identified: (1) little change in symptomatic status ("NO"), comprising 24.9% of participants, with a 72-week remission rate of 25.3%; (2) slow, steady improvement ("SLOW"), comprising 47.9% of participants, with a remission rate of 60.0%, and (3) rapid symptom response ("GO"), comprising 27.2% of participants, with a remission rate of 85.7%. Higher baseline CDRS-R (p<0.001) and poorer functioning (p=0.03) were the strongest discriminators between NO and GO. Higher baseline CDRS (p<0.001) and scores on the Mania Rating Scale (MRS) (p=0.01) were the strongest discriminators between SLOW and GO. Other variables differentiating GO from both NO and from SLOW, were better baseline functioning, lower hopelessness, and lower family conflict. Both NO and SLOW showed increases on the MRS over time compared to GO (ps ≤ 0.04), and increasing MRS was strongly associated with lack of remission by 72 weeks (p=0.02). LIMITATIONS: High rate of open treatment by the end of the follow-up period creates difficulty in drawing clear inferences about the long-term impact of initial randomization.
conclusionAlong with depressive severity, sub-syndromal manic symptoms, at baseline, and over time emerged as important predictors and correlates of poor outcome in this sample. Further research is needed on the treatment of severe depression, and on the assessment and management of sub-syndromal manic symptoms in treatment resistant depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.