ArticleAnalytical chemistry2012
Fiducial markers for combined 3-dimensional mass spectrometric and optical tissue imaging.
Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- FluoMALDI Microscopy: Matrix Co-Crystallization Simultaneously Enhances Fluorescence and MALDI Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- DISC-3D: dual-hydrogel system enhances optical imaging and enables correlative mass spectrometry imaging of invading multicellular tumor spheroids.Scientific reports · 2023Article
- An overview of image registration for aligning mass spectrometry imaging with clinically relevant imaging modalities.Journal of mass spectrometry and advances in the clinical lab · 2022Article
- Experimental and Data Analysis Considerations for Three-Dimensional Mass Spectrometry Imaging in Biomedical Research.Molecular imaging and biology · 2021Review
- 3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma.Journal of proteomics · 2016Article
- MALDI-Mass Spectrometric Imaging Revealing Hypoxia-Driven Lipids and Proteins in a Breast Tumor Model.Analytical chemistry · 2015Article
- Precise Anatomic Localization of Accumulated Lipids in Mfp2 Deficient Murine Brains Through Automated Registration of SIMS Images to the Allen Brain Atlas.Journal of the American Society for Mass Spectrometry · 2015Article
- Mass spectrometry coupled to imaging techniques: the better the view the greater the challenge.Frontiers in physiology · 2015Article
- Mass spectrometric imaging of red fluorescent protein in breast tumor xenografts.Journal of the American Society for Mass Spectrometry · 2013Article
- High energy collisions on tandem time-of-flight mass spectrometers.Journal of the American Society for Mass Spectrometry · 2013Article
- Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research.Chemical reviews · 2013Review
- Mass spectrometry images acylcarnitines, phosphatidylcholines, and sphingomyelin in MDA-MB-231 breast tumor models.Journal of lipid research · 2013Article
- Localized hypoxia results in spatially heterogeneous metabolic signatures in breast tumor models.Neoplasia (New York, N.Y.) · 2012Article
- Advances in mass spectrometry imaging for spatial cancer metabolomics.Mass spectrometry reviewsReview
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7 authors.
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Abstract
Mass spectrometric imaging (MSI) has become widely used in the analysis of a variety of biological surfaces. Biological samples are spatially, morphologically, and metabolically complex. Multimodal molecular imaging is an emerging approach that is capable of dealing with this complexity. In a multimodal approach, different imaging modalities can provide precise information about the local molecular composition of the surfaces. Images obtained by MSI can be coregistered with images obtained by other molecular imaging techniques such as microscopic images of fluorescent protein expression or histologically stained sections. In order to properly coregister images from different modalities, each tissue section must contain points of reference, which are visible in all data sets. Here, we report a newly developed coregistration technique using fiducial markers such as cresyl violet, Ponceau S, and bromophenol blue that possess a combination of optical and molecular properties that result in a clear mass spectrometric signature. We describe these fiducial markers and demonstrate an application that allows accurate coregistration and 3-dimensional reconstruction of serial histological and fluorescent microscopic images with MSI images of thin tissue sections from a breast tumor model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.