ArticleJournal of the American Geriatrics Society2012
Serum 25-hydroxyvitamin D, transitions between frailty states, and mortality in older adults: the Invecchiare in Chianti Study.
Article in Journal of the American Geriatrics Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Association between 25-hydroxy vitamin D levels and risk of frailty and pre-frailty in elderly adults: a systematic review and dose-response meta-analysis of epidemiologic studies with GRADE assessment.Journal of translational medicine · 2025Pooled it
- Low Vitamin D Levels and Frailty Status in Older Adults: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis.BMC geriatrics · 2018Pooled it
- Cognitive Dysfunction in Urban-Community Dwelling Prefrail Older Subjects.The journal of nutrition, health & aging · 2018Trial
- Molecular predictors of incident frailty: a systematic review and critical appraisal of longitudinal evidence.GeroScience · 2026Review
- Predictors of Frailty in the Elderly Population: A Cross-Sectional Study at a Tertiary Care Center.Cureus · 2022Article
- Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?Advances in geriatric medicine and research · 2021Article
- Approaches to the diagnosis and prevention of frailty.Aging clinical and experimental research · 2020Review
- Operationalization of a frailty index among older adults in the InCHIANTI study: predictive ability for all-cause and cardiovascular disease mortality.Aging clinical and experimental research · 2020Article
- Plasma Klotho and Frailty in Older Adults: Findings From the InCHIANTI Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- The association between 25-hydroxyvitamin D concentration, physical performance and frailty status in older adults.European journal of nutrition · 2019Article
- Current and emerging biomarkers of frailty in the elderly.Clinical interventions in aging · 2019Review
- What is the duration of life expectancy in the state of frailty? Estimates in the SIPAF study.European journal of ageing · 2018Article
- Nonandrogenic Anabolic Hormones Predict Risk of Frailty: European Male Ageing Study Prospective Data.The Journal of clinical endocrinology and metabolism · 2017Observational
- The Association of Vitamin D Deficiency and Incident Frailty in Older Women: The Role of Cardiometabolic Diseases.Journal of the American Geriatrics Society · 2017Observational
- Screening for frailty: older populations and older individuals.Public health reviews · 2016Article
- Is the 25-Hydroxy-Vitamin D Serum Concentration a Good Marker of Frailty?The journal of nutrition, health & aging · 2016Article
- Clinical and Functional Characterization of Pre-frailty among Elderly Patients Consulting Primary Care Centres.The journal of nutrition, health & aging · 2016Article
- Association of habitual dietary resveratrol exposure with the development of frailty in older age: the Invecchiare in Chianti study.The American journal of clinical nutrition · 2015Article
- Serum 25-Hydroxyvitamin D, Plasma Klotho, and Lower-Extremity Physical Performance Among Older Adults: Findings From the InCHIANTI Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
objectivesTo assess whether serum 25-hydroxyvitamin D (25(OH)D) concentrations relate to transitions between the states of robustness, prefrailty, and frailty and to mortality in older adults.
designThe Invecchiare in Chianti (InCHIANTI) Study, a prospective cohort study.
settingTuscany, Italy.
participantsAdults aged 65 and older (N = 1,155). MEASUREMENTS: Serum 25(OH)D concentrations measured at baseline; frailty state (robust, prefrail, frail) assessed at baseline and 3 and 6 years after enrollment; and vital status determined 3 and 6 years after enrollment.
resultsThe median (interquartile range) 25(OH)D concentration was 16.0 ng/mL (10.4-25.6 ng/mL; multiply by 2.496 to convert to nmol/L). Prefrail participants with 25(OH)D levels less than 20 ng/mL were 8.9% (95% confidence interval (CI) = 2.5-15.2%) more likely to die, 3.0% (95% CI = -5.6-14.6%) more likely to become frail, and 7.7% (95% CI = -3.5-18.7%) less likely to become robust than prefrail participants with 25(OH)D levels of 20 ng/mL or more. In prefrail participants, each 5-ng/mL decrement of continuous 25(OH)D was associated with 1.46 times higher odds of dying (95% CI = 1.18-2.07) and 1.13 higher odds of incident frailty (95% CI = 0.90-1.39) than with recovery of robustness. Transitions from robustness or frailty were not associated with 25(OH)D levels.
conclusionResults provide evidence that prefrailty is an "at risk" state from which older adults with high 25(OH)D levels are more likely to recover than to decline, but high 25(OH)D levels were not associated with recovery from frailty. Thus, 25(OH)D levels should be investigated as a potential therapy to treat prefrailty and prevent further decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.