ArticleJournal of mathematical neuroscience2011
Spontaneous voltage oscillations and response dynamics of a Hodgkin-Huxley type model of sensory hair cells.
Article in Journal of mathematical neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 43 citations in OpenAlex.
- Criticality and chaos in auditory and vestibular sensing.Scientific reports · 2024Article
- Review of chaos in hair-cell dynamics.Frontiers in neurology · 2024Review
- Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells.Scientific reports · 2019Article
- Chaotic Dynamics of Inner Ear Hair Cells.Scientific reports · 2018Article
- A model of signal processing at the isolated hair cell of the frog semicircular canal.Journal of computational neuroscience · 2017Article
- Electrogenic properties of the Na⁺/K⁺ ATPase control transitions between normal and pathological brain states.Journal of neurophysiology · 2015Article
- Hair cell-type dependent expression of basolateral ion channels shapes response dynamics in the frog utricle.Frontiers in cellular neuroscience · 2015Article
- Sensory transduction at the frog semicircular canal: how hair cell membrane potential controls junctional transmission.Frontiers in cellular neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
We employ a Hodgkin-Huxley type model of basolateral ionic currents in bullfrog saccular hair cells to study the genesis of spontaneous voltage oscillations and their role in shaping the response of the hair cell to external mechanical stimuli. Consistent with recent experimental reports, we find that the spontaneous dynamics of the model can be categorized using conductance parameters of calcium activated potassium, inward rectifier potassium, and mechano-electrical transduction ionic currents. The model is demonstrated to exhibit a broad spectrum of autonomous rhythmic activity, including periodic and quasiperiodic oscillations with two independent frequencies as well as various regular and chaotic bursting patterns. Complex patterns of spontaneous oscillations in the model emerge at small values of the conductance of Ca(2+) activated potassium currents. These patterns are significantly affected by thermal fluctuations of the mechano-electrical transduction current. We show that self-sustained regular voltage oscillations lead to enhanced and sharply tuned sensitivity of the hair cell to weak mechanical periodic stimuli. While regimes of chaotic oscillations are argued to result in poor tuning to sinusoidal driving, chaotically oscillating cells do provide a high sensitivity to low-frequency variations of external stimuli.
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Registered trials
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