ArticleActa histochemica et cytochemica2011
Expression of podoplanin and classical cadherins in salivary gland epithelial cells of klotho-deficient mice.
Article in Acta histochemica et cytochemica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Can salivary phosphate levels be an early biomarker to monitor the evolvement of obesity?Contributions to nephrology · 2013Trial
- Podoplanin is dispensable for mineralized tissue formation and maintenance in the Swiss outbred mouse background.Genesis (New York, N.Y. : 2000) · 2021Article
- Immunophenotypical alterations with impact on the epithelial-mesenchymal transition (EMT) process in salivary gland adenoid cystic carcinomas.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie · 2020Article
- LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer.Oncotarget · 2018Article
- Article
- Distribution of podoplanin-expressing cells in the mouse nervous systems.Acta histochemica et cytochemica · 2013Article
- Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice.Acta histochemica et cytochemica · 2013Article
- Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions.Acta histochemica et cytochemica · 2013Article
- An in vitro culture system for long-term expansion of epithelial and mesenchymal salivary gland cells: role of TGF-β1 in salivary gland epithelial and mesenchymal differentiation.BioMed research international · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have recently shown that salivary gland myoepithelial cells express podoplanin. Podoplanin indirectly binds the actin filament network which links classical cadherins. The study here is aimed to investigate the expression of podoplanin and cadherins on salivary gland myoepithelial cells and the changes in the aging cells using klotho-deficient (kl/kl) mice. The submandibular glands of kl/kl mouse lack granular ducts which express klotho in wild type mice, suggesting that klotho may be a gene responsible for granular duct development. Although aging resulted in growth suppression of myoepithelial cells because of the sparse distribution of the cells in kl/kl mouse salivary glands, the expression of podoplanin and E-cadherin was shown in aging myoepithelial cells. It is thought that podoplanin participates in the actin-E-cadherin networks which are maintained in aging myoepithelial cells. It was also shown that granular ducts were filled with P-cadherin, and that the P-cadherin amount was larger in the wild type mouse submandibular glands than in the sublingual and parotid glands of wild type mouse, and in the submandibular glands of kl/kl mouse. These findings suggest that the granular duct is an organ secreting soluble P-cadherin into the saliva.
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