ReviewWorld journal of pediatrics : WJP2012
Diagnosis and management of cow's milk protein allergy in infants.
Review in World journal of pediatrics : WJP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Probiotics for cow's milk protein allergy: a systematic review of randomized controlled trials.European journal of pediatrics · 2019Pooled it
- A Case Report of Familial Chylomicronemia Syndrome With Infantile Onset: One-Year Follow-Up on Lipid Profile and Growth Development.Clinical case reports · 2026Article
- Peripheral skin temperature during hospitalization and allergic disorders in non-NICU neonates >35 weeks.iScience · 2026Article
- [Interpretation of key points from the "Expert Consensus on Diagnosis and Management of Neonatal Cow Milk Protein Allergy (2023)"].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Cow's milk protein allergy in infants and children.Paediatrics & child health · 2024Review
- L'allergie aux protéines du lait de vache chez les nourrissons et les enfants.Paediatrics & child health · 2024Review
- Review
- Article
- The use of amino acid formulas in pediatric patients with allergy to cow's milk proteins: Recommendations from a group of experts.Frontiers in pediatrics · 2023Review
- Symptom's resolution and growth outcome of children with cow's milk protein allergy consuming two hydrolyzed formulas: A retrospective study in Mexico.Frontiers in allergy · 2023Article
- Consensus statement on the epidemiology, diagnosis, prevention, and management of cow's milk protein allergy in the Middle East: a modified Delphi-based study.World journal of pediatrics : WJP · 2021Article
- A free amino acid-based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey.Immunity, inflammation and disease · 2020Article
- Early-life gut microbiome and cow's milk allergy- a prospective case - control 6-month follow-up study.Saudi journal of biological sciences · 2018Article
- [Research advances in the relationship between cow's milk allergy and gastroesoph-ageal reflux in infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Review
- Remaining symptoms in half the children treated for milk allergy.European journal of pediatrics · 2015Observational
- Middle East Consensus Statement on the Prevention, Diagnosis, and Management of Cow's Milk Protein Allergy.Pediatric gastroenterology, hepatology & nutrition · 2014Review
- Two single group, prospective, baseline-controlled feeding studies in infants and children with chronic diarrhea fed a hypoallergenic free amino acid-based formula.BMC pediatrics · 2014Article
- Nutritional management and follow up of infants and children with food allergy: Italian Society of Pediatric Nutrition/Italian Society of Pediatric Allergy and Immunology Task Force Position Statement.Italian journal of pediatrics · 2014Article
- Evaluation of a free amino acid-based formula in infants with presumptive food protein-induced proctocolitis.SAGE open medicine · 2014Article
- Overview of evidence in prevention and aetiology of food allergy: a review of systematic reviews.International journal of environmental research and public health · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCow's milk protein allergy (CMPA) is frequently suspected in infants with a variety of symptoms. A thorough history and careful clinical examination are necessary to exclude other underlying diseases and to evaluate the severity of the suspected allergy. Care should be taken to diagnose CMPA adequately to avoid an unnecessary diet. DATA SOURCES: We make recommendations based on systematic literature searches using the best-available evidence from PubMed, Cumulative Index to Nursing and Allied Health Literature, and bibliographies.
resultsSkin prick tests, patch tests and serum specific IgE are only indicative of CMPA. Breastfed infants have a decreased risk of developing CMPA; an elimination diet for the mother is indicated if CMPA is confirmed. If a food challenge is positive in formula fed infants, an extensively hydrolysed formula and cow's milk-free diet is recommended. If symptoms do not improve, an amino acid based formula should be considered. In severe CMPA with life-threatening symptoms, an amino-acid formula is recommended.
conclusionsElimination diet by a double-blind placebo controlled food challenge is the gold standard for diagnosis. Elimination of the offending allergen from the infants' diet is the main treatment principle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.