ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2012
Hormonal and dietary influences on true fractional calcium absorption in women: role of obesity.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00472654 (Nutritional Regulation of Bone - Aim 3), which is not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nutritional Regulation of Bone - Aim 3
Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Trial
- Vitamin D supplementation and calcium absorption during caloric restriction: a randomized double-blind trial.The American journal of clinical nutrition · 2013Trial
- The impact of obesity on bone health: molecular pathways, metabolic interactions, and associated pathologies.International journal of obesity (2005) · 2026Review
- Intestinal Calcium Absorption Decreases After Laparoscopic Sleeve Gastrectomy Despite Optimization of Vitamin D Status.The Journal of clinical endocrinology and metabolism · 2023Observational
- Multi-element Analysis of Brain Regions from South African Cadavers.Biological trace element research · 2021Article
- Vitamin D and intestinal calcium transport after bariatric surgery.The Journal of steroid biochemistry and molecular biology · 2017Review
- The associations of vitamin D status and dietary calcium with the metabolic syndrome: an analysis of the Victorian Health Monitor survey.Public health nutrition · 2017Article
- Obesity is a concern for bone health with aging.Nutrition research (New York, N.Y.) · 2017Review
- High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice.Nutrition research (New York, N.Y.) · 2016Article
- Article
- Preservation of high-fat diet-induced femoral trabecular bone loss through genetic target of TNF-α.Endocrine · 2015Article
- Factors associated with calcium absorption in postmenopausal women: a post hoc analysis of dual-isotope studies.Journal of the Academy of Nutrition and Dietetics · 2014Article
- Gene-by-diet interactions influence calcium absorption and bone density in mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Increased vitamin D-binding protein and decreased free 25(OH)D in obese women of reproductive age.European journal of nutrition · 2014Article
- Vitamin D and obesity.Nutrients · 2013Review
- Weight Loss-Induced Reduction of Bone Mineral Density in Older Adults with Obesity.Journal of nutrition in gerontology and geriatricsReview
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledThe goal in this study was to examine the hormonal and dietary predictors of true fractional Ca absorption (TFCA) in adult women and to determine whether TFCA differs due to body weight. Results showed that TFCA is higher in obese individuals and dietary fat, estradiol, and 1,25-dihydroxy vitamin D are the most significant positive predictors of TFCA in adult women.
introductionCalcium absorption is an important determinant of calcium balance and is influenced by several factors. Previous studies have identified that age, intake of protein, fat and fiber, and hormones such as 1, 25-dihyroxyvitamin D (1,25(OH)(2)D(3)) influence absorption. The determinants of TFCA using the double isotope method, the gold standard estimate of absorption, have not been examined previously in adult women nor has the role of obesity been addressed.
methodsIn this study, we examined the hormonal and dietary predictors of TFCA in adult women with a wide range of age, body weights, and nutrient intake. TFCA was measured using dual stable isotope ((42)Ca and (43)Ca) technique. Serum was analyzed for bone-regulating hormones, and dietary information was obtained through food records. The independent dietary factors and hormonal predictors (25-hydroxyvitamin D, 1,25(OH)(2)D(3), parathyroid hormone, and estradiol) of TFCA were analyzed using multiple regression analysis.
resultsTwo hundred twenty-nine women aged 54 ± 11 years old (24-75 years) and with BMI of 31 ± 7.0 kg/m(2) were eligible and were categorized into tertiles of body mass index (BMI) into leaner, overweight, and obese. In the entire group of women, total fat intake, estradiol, and 1,25(OH)(2)D(3) are significant positive predictors (p < 0.05). As expected, age is a significant negative predictor of TFCA (R (2) = 26%). TFCA is higher in obese women compared to non-obese women (p < 0.05).
conclusionTogether, these data show that dietary fat is the most significant positive predictor of TFCA which may have implications for dietary intake for non-obese individuals who are more likely to have lower and potentially compromised Ca absorption.
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