ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2012
Critical discussion of evaluation parameters for inter-observer variability in target definition for radiation therapy.
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interobserver variability studies in diagnostic imaging: a methodological systematic review.The British journal of radiology · 2023Pooled it
- Repeatability of radiomics studies in colorectal cancer: a systematic review.BMC gastroenterology · 2023Pooled it
- Comparison of prostate delineation on multimodality imaging for MR-guided radiotherapy.The British journal of radiology · 2019Trial
- Consequences of anorectal cancer atlas implementation in the cooperative group setting: radiobiologic analysis of a prospective randomized in silico target delineation study.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2014Trial
- Prospective randomized double-blind study of atlas-based organ-at-risk autosegmentation-assisted radiation planning in head and neck cancer.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2014Trial
- Radiotherapy quality assurance in the PRO-GLIO trial: results from a dummy run comparing experts across twelve institutions in two Scandinavian countries.Clinical and translational radiation oncology · 2026Article
- Quantitative assessment of inter-observer consistency in target volume delineation following breast-conserving surgery and mastectomy.Frontiers in oncology · 2026Article
- Consistency evaluation and performance optimization of deep learning-based auto-contouring for nasopharyngeal carcinoma.Scientific reports · 2025Article
- Anatomical and dosimetric variations during volumetric modulated arc therapy in patients with locally advanced nasopharyngeal carcinoma after induction therapy: Implications for adaptive radiation therapy.Clinical and translational radiation oncology · 2024Article
- Clinical implementation of failure modes and effects analysis for gynecological high-dose-rate brachytherapy.Journal of contemporary brachytherapy · 2024Article
- A single center, inter-observer evaluation of vestibular schwannoma stereotactic radiosurgery and its dosimetric impact.Journal of radiosurgery and SBRT · 2024Article
- Validation of a deep-learning segmentation model for adult and pediatric head and neck radiotherapy in different patient positions.Physics and imaging in radiation oncology · 2024Article
- Deep learning model improves tumor-infiltrating lymphocyte evaluation and therapeutic response prediction in breast cancer.NPJ breast cancer · 2023Article
- Clinical assessment of a novel machine-learning automated contouring tool for radiotherapy planning.Journal of applied clinical medical physics · 2023Article
- Clinical validation of a semi-automated segmentation algorithm for target volume definition on planning CT and CBCT in stereotactic body radiotherapy (SBRT) for peripheral lung lesions.Journal of medical radiation sciences · 2023Article
- Multicenter comparison of measures for quantitative evaluation of contouring in radiotherapy.Physics and imaging in radiation oncology · 2022Article
- Clinical validation of deep learning algorithms for radiotherapy targeting of non-small-cell lung cancer: an observational study.The Lancet. Digital health · 2022Observational
- Delineation uncertainties of tumour volumes on MRI of head and neck cancer patients.Clinical and translational radiation oncology · 2022Article
- Advantages of TRUS-based delineation for high-dose-rate prostate brachytherapy planning.Journal of contemporary brachytherapy · 2022Article
- Pretreatment Computed Tomography-Based Machine Learning Models to Predict Outcomes in Hepatocellular Carcinoma Patients who Received Combined Treatment of Trans-Arterial Chemoembolization and Tyrosine Kinase Inhibitor.Frontiers in bioengineering and biotechnology · 2022Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeInter-observer studies represent a valid method for the evaluation of target definition uncertainties and contouring guidelines. However, data from the literature do not yet give clear guidelines for reporting contouring variability. Thus, the purpose of this work was to compare and discuss various methods to determine variability on the basis of clinical cases and a literature review. PATIENTS AND
methodsIn this study, 7 prostate and 8 lung cases were contoured on CT images by 8 experienced observers. Analysis of variability included descriptive statistics, calculation of overlap measures, and statistical measures of agreement. Cross tables with ratios and correlations were established for overlap parameters.
resultsIt was shown that the minimal set of parameters to be reported should include at least one of three volume overlap measures (i.e., generalized conformity index, Jaccard coefficient, or conformation number). High correlation between these parameters and scatter of the results was observed.
conclusionA combination of descriptive statistics, overlap measure, and statistical measure of agreement or reliability analysis is required to fully report the interrater variability in delineation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.