Trial reportAmerican journal of respiratory and critical care medicine2012
Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial.
Trial report in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00751322 (Project 2), which is not on this map. Cited by 31 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Project 2 (Mayo): Transfusion-Induced Alterations of Pulmonary and Immune Function in Mechanically Ventilated Patients
Who cites it
31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Transfusion of red blood cells stored for shorter versus longer duration for all conditions.The Cochrane database of systematic reviews · 2018Pooled it
- Effects of shorter versus longer storage time of transfused red blood cells in adult ICU patients: a systematic review with meta-analysis and Trial Sequential Analysis.Intensive care medicine · 2018Pooled it
- Effects of packed red blood cell storage duration on post-transfusion clinical outcomes: a meta-analysis and systematic review.Intensive care medicine · 2015Pooled it
- Prolonged storage of packed red blood cells for blood transfusion.The Cochrane database of systematic reviews · 2015Pooled it
- Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review.Critical care (London, England) · 2013Pooled it
- Effects of blood storage age on immune, coagulation, and nitric oxide parameters in transfused patients undergoing cardiac surgery.Transfusion · 2019Trial
- A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery.Anesthesiology · 2015Trial
- Storage duration of packed red blood cells transfused during veno-venous extracorporeal membrane oxygenation is associated with elevated pulmonary artery pressure and lung injury in a sheep model.Critical care (London, England) · 2025Article
- Effects of transfusing older red blood cells on patient outcomes in critical illness: A retrospective cohort study.Vox sanguinis · 2025Observational
- Effect of storage duration on outcome of patients receiving red blood cell in emergency department.Scientific reports · 2024Article
- Effect of Age of Transfused Red Blood Cell Units on Clinical Outcomes in Critically Ill Patients.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024Article
- Microvesicles from stored red blood cells induce P-selectin and von Willebrand factor release from endothelial cells via a protein kinase C-dependent mechanism.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2024Article
- Effects of transfusing older red blood cells and platelets on obstetric patient outcomes: A retrospective cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2024Article
- Improving packed red blood cell storage with a high-viscosity buffered storage solution.Surgery · 2022Article
- Landmark Papers on Blood and Component Transfusion Therapy in the Critically Ill: A Critical Analysis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
- Age of Red Cells for Transfusion and Outcomes in Critically Ill Patients: A Meta-Analysis.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2019Article
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- TACO and TRALI: biology, risk factors, and prevention strategies.Hematology. American Society of Hematology. Education Program · 2018Review
- Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of transfusion.Surgery · 2018Article
- Short-term effects of stored homologous red blood cell transfusion on cardiorespiratory function and inflammation: an experimental study in a hypovolemia model.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
rationaleTransfusion-related pulmonary complications are leading causes of morbidity and mortality attributed to transfusion. Observational studies suggest an important role for red blood cell (RBC) storage duration in these adverse outcomes.
objectivesTo evaluate the impact of RBC storage duration on short-term pulmonary function as well as immunologic and coagulation status in mechanically ventilated patients receiving RBC transfusion.
methodsThis is a double-blind, randomized, clinical trial comparing fresh (≤5 d of storage) versus standard issue single-unit RBC transfusion in adult intubated and mechanically ventilated patients. The primary outcome is the change in pulmonary gas exchange as assessed by the partial pressure of arterial oxygen to fraction of inspired oxygen concentration ratio (ΔPa(O(2))/Fi(O(2))). Secondary outcomes include changes in immune and coagulation status. MEASUREMENTS AND MAIN
resultsFifty patients were randomized to receive fresh RBCs and an additional 50 patients to standard issue RBCs. Median storage age was 4.0 days (interquartile range, 3.0-5.0) and 26.5 days (interquartile range, 21.0-36.0) in the fresh RBC group and standard issue RBC group, respectively. No differences were noted in the primary outcome of ΔPa(O(2))/Fi(O(2)) (difference between the mean ΔPa(O(2))/Fi(O(2)) in the standard issue RBC group vs. the fresh RBC group, -11.5; 95% confidence interval, -35.3 to 12.3; P = 0.22). Similarly, no significant differences were noted in markers of immunologic or coagulation status.
conclusionsIn this randomized clinical trial, no differences were noted in early measures of pulmonary function or in immunologic or coagulation status when comparing fresh versus standard issue single-unit RBC transfusion. Clinical trial registered with ClinicalTrials.gov (NCT00751322).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.