ArticleAmerican journal of respiratory and critical care medicine2012
Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma.
Article in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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Who cites it
43 citing papers in PubMed, 79 citations in OpenAlex.
- From vector to allergen: exploring the immunology of tick-triggered α-Gal syndrome.Frontiers in immunology · 2026Review
- Allergic reactions associated with tsetse fly bites.Annals of medicine · 2025Article
- Alpha-Gal Syndrome in the Heartland: Dietary Restrictions, Public Awareness, and Systemic Barriers in Rural Kansas.Nutrients · 2025Article
- A Review of Alpha-Gal Syndrome for the Infectious Diseases Practitioner.Open forum infectious diseases · 2025Review
- The Immunology of Alpha-Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat.Immunological reviews · 2025Review
- Review
- Innovative Metrics for Reporting and Comparing the Glycan Structural Profile in Biotherapeutics.Molecules (Basel, Switzerland) · 2023Article
- Biomanufacturing of Axon-Based Tissue Engineered Nerve Grafts Using Porcine GalSafe Neurons.Tissue engineering. Part A · 2021Article
- Diagnostic testing for galactose-alpha-1,3-galactose, United States, 2010 to 2018.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Article
- Lessons in Innate and Allergic Immunity From Dust Mite Feces and Tick Bites.Frontiers in allergy · 2021Review
- Alpha-Gal Syndrome in Children: Peculiarities of a "Tick-Borne" Allergic Disease.Frontiers in pediatrics · 2021Review
- Tick Saliva and the Alpha-Gal Syndrome: Finding a Needle in a Haystack.Frontiers in cellular and infection microbiology · 2021Review
- Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients.Expert review of clinical immunology · 2020Review
- Infection withVaccines · 2020Article
- Diagnosis and Management of Patients with the α-Gal Syndrome.The journal of allergy and clinical immunology. In practice · 2020Review
- B Cell Responses in the Development of Mammalian Meat Allergy.Frontiers in immunology · 2020Review
- Cutaneous Exposure to Clinically Relevant Lone Star Ticks Promotes IgE Production and Hypersensitivity through CD4Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Ingestion of mammalian meat and alpha-gal allergy: Clinical relevance in primary care.African journal of primary health care & family medicine · 2019Review
- Environmental and Molecular Drivers of the α-Gal Syndrome.Frontiers in immunology · 2019Review
- The quantity and quality of α-gal-specific antibodies differ in individuals with and without delayed red meat allergy.Allergy · 2017Article
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 6 countries.
Funding
Abstract
rationaleIgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose (α-gal) are common in the southeastern United States. These antibodies, which are induced by ectoparasitic ticks, can give rise to positive skin tests or serum assays with cat extract.
objectivesTo evaluate the relationship between IgE antibodies to α-gal and asthma, and compare this with the relationship between asthma and IgE antibodies to Fel d 1 and other protein allergens.
methodsPatients being investigated for recurrent anaphylaxis, angioedema, or acute urticaria underwent spirometry, exhaled nitric oxide, questionnaires, and serum IgE antibody assays. The results were compared with control subjects and cohorts from the emergency department in Virginia (n = 130), northern Sweden (n = 963), and rural Kenya (n = 131). MEASUREMENTS AND MAIN
resultsPatients in Virginia with high-titer IgE antibodies to α-gal had normal lung function, low levels of exhaled nitric oxide, and low prevalence of asthma symptoms. Among patients in the emergency department and children in Kenya, there was no association between IgE antibodies to α-gal and asthma (odds ratios, 1.04 and 0.75, respectively). In Sweden, IgE antibodies to cat were closely correlated with IgE antibodies to Fel d 1 (r = 0.83) and to asthma (P < 0.001).
conclusionsThese results provide a model of an ectoparasite-induced specific IgE response that can increase total serum IgE without creating a risk for asthma, and further evidence that the main allergens that are causally related to asthma are those that are inhaled.
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Registered trials
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