ArticleActa crystallographica. Section D, Biological crystallography2012
Global radiation damage at 300 and 260 K with dose rates approaching 1 MGy s⁻¹.
Article in Acta crystallographica. Section D, Biological crystallography, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Damage-limited resolution for X-ray and electron microscopy of organic specimens.Acta crystallographica. Section D, Structural biology · 2026Article
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- Evolution of macromolecular crystallography beamlines at the Swiss Light Source and SwissFEL.Journal of synchrotron radiation · 2025Article
- Fast product release requires active-site water dynamics in carbonic anhydrase.Nature communications · 2025Article
- Cryo2RT: a high-throughput method for room-temperature macromolecular crystallography from cryo-cooled crystals.Acta crystallographica. Section D, Structural biology · 2024Article
- XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures.Acta crystallographica. Section D, Structural biology · 2024Article
- Probing ligand binding of endothiapepsin by `temperature-resolved' macromolecular crystallography.Acta crystallographica. Section D, Structural biology · 2022Article
- Instrumentation and experimental procedures for robust collection of X-ray diffraction data from protein crystals across physiological temperatures.Journal of applied crystallography · 2020Article
- Radiation damage and dose limits in serial synchrotron crystallography at cryo- and room temperatures.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Resolving polymorphs and radiation-driven effects in microcrystals using fixed-target serial synchrotron crystallography.Acta crystallographica. Section D, Structural biology · 2019Article
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- Quantifying radiation damage in biomolecular small-angle X-ray scattering.Journal of applied crystallography · 2016Article
- Ultrasonic acoustic levitation for fast frame rate X-ray protein crystallography at room temperature.Scientific reports · 2016Article
- Practical macromolecular cryocrystallography.Acta crystallographica. Section F, Structural biology communications · 2015Review
- Temperature-dependent radiation sensitivity and order of 70S ribosome crystals.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Matching X-ray beam and detector properties to protein crystals of different perfection.Journal of synchrotron radiation · 2014Article
- Exploiting fast detectors to enter a new dimension in room-temperature crystallography.Acta crystallographica. Section D, Biological crystallography · 2014Article
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6 authors.
Funding
Abstract
Global radiation damage to 19 thaumatin crystals has been measured using dose rates from 3 to 680 kGy s⁻¹. At room temperature damage per unit dose appears to be roughly independent of dose rate, suggesting that the timescales for important damage processes are less than ∼1 s. However, at T = 260 K approximately half of the global damage manifested at dose rates of ∼10 kGy s⁻¹ can be outrun by collecting data at 680 kGy s⁻¹. Appreciable sample-to-sample variability in global radiation sensitivity at fixed dose rate is observed. This variability cannot be accounted for by errors in dose calculation, crystal slippage or the size of the data sets in the assay.
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