ArticleNature neuroscience2012
Recent advances in the genetic epidemiology and molecular genetics of substance use disorders.
Article in Nature neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Genome-wide meta-analyses of cross substance use disorders in diverse populations.Molecular psychiatry · 2026Pooled it
- Interleukin 4 gene polymorphism (-589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies.BMC immunology · 2020Pooled it
- From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation.Pharmacogenomics · 2018Pooled it
- Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.JAMA psychiatry · 2017Pooled it
- Shared genetic effects among schizophrenia, substance use disorder, and hippocampal volume in a multiplex extended pedigree sample.Schizophrenia research · 2026Article
- The familial aggregation and co-aggregation of drug use disorder and alcohol use disorder in siblings of affected individuals born 1950-1990: A birth cohort exposed to rising rates of drug use disorder.Psychological medicine · 2025Article
- Article
- Substance Use and Concurrent Disorders: Current Context and the Need for Treatment Integration.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2025Article
- Perspectives regarding cannabis use: Results from a qualitative study of individuals engaged in substance use treatment in Georgia and Connecticut.Drug and alcohol dependence reports · 2024Article
- Media framings of the role of genomics in "addiction" in the United States from 2015 to 2019: Individualized risk, biomedical expertise, and the limits of destigmatization.Public understanding of science (Bristol, England) · 2024Article
- Beyond the factor indeterminacy problem using genome-wide association data.Nature human behaviour · 2024Review
- Risk assessment of substance use disorders based on the human leukocyte antigen (HLA).Scientific reports · 2023Article
- Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.Nature. Mental health · 2023Article
- Genetic and Environmental Variation in Continuous Phenotypes in the ABCD Study®.Behavior genetics · 2023Article
- Magnitude and Associated Factors of Psychoactive Substance Use among Youths at Selected Administrative Towns of North Shewa Zone, Amhara Region, Ethiopia.Journal of addiction · 2023Article
- Genetic and environmental influences on early-age susceptibility and initiation of nicotine-containing product use: A twin-pairs study.Tobacco prevention & cessation · 2023Article
- The Genetically Informed Neurobiology of Addiction (GINA) model.Nature reviews. Neuroscience · 2023Review
- Association of Polymorphism within the Putative miRNA Target Site in the 3'UTR Region of theInternational journal of environmental research and public health · 2022Article
- Determining the stability of genome-wide factors in BMI between ages 40 to 69 years.PLoS genetics · 2022Article
- Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
This article reviews current advances in the genetics of substance use disorders (SUDs). Both genetic and environmental sources of risk are required to develop a complete picture of SUD etiology. Genetic sources of risk for SUDs are not highly substance specific in their effects. Genetic and environmental risks for SUDs typically do not only add together but also interact with each other over development. Risk gene identification for SUDs has been difficult, with one recent success in identifying nicotinic receptor variants that affect risk for nicotine dependence. The impact of genetic variants on SUD risk will individually be small. Although genetic epidemiologic methods are giving us an increasingly accurate map of broad causal pathways to SUDs, gene discovery will be needed to identify the specific biological systems. Identifying these risk genes and understanding their action will require large clinical samples, and interaction between these studies and work in model organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.