ArticleParasitology research2012
Evaluation of the schistosomicidal activity of the steroidal alkaloids from Solanum lycocarpum fruits.
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 46 citations in OpenAlex.
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- Health Benefits of the Alkaloids from Lobeira (Plants (Basel, Switzerland) · 2024Review
- Therapeutic Potential ofDrug design, development and therapy · 2024Review
- Antischistosomal effects ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Cytotoxic and chemosensitizing effects of glycoalkaloidic extract on 2D and 3D models using RT4 and patient derived xenografts bladder cancer cells.Materials science & engineering. C, Materials for biological applications · 2021Article
- Review
- Efficacy ofJournal of traditional and complementary medicine · 2019Article
- The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review.Natural products and bioprospecting · 2019Review
- Efficacy of FourMedicines (Basel, Switzerland) · 2018Article
- Bioactive Compounds Found in Brazilian Cerrado Fruits.International journal of molecular sciences · 2015Review
- Schistosomicidal, hepatoprotective and antioxidant activities of the methanolic fraction from Clerodendrum umbellatum Poir leaves aqueous extract in Schistosoma mansoni infection in mice.BMC complementary and alternative medicine · 2015Article
- Natural products as leads in schistosome drug discovery.Molecules (Basel, Switzerland) · 2015Article
- A penta-substituted pyridine alkaloid from the rhizome of Jatropha elliptica (Pohl) Muell. Arg. is active against Schistosoma mansoni and Biomphalaria glabrata.Parasitology research · 2014Article
- Anthelmintic activity of carvacryl acetate against Schistosoma mansoni.Parasitology research · 2013Article
- Comparative Molluscicidal and Schistosomicidal Potentiality of TwoPharmacognosy researchArticle
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solanum lycocarpum (Solanaceae), a Brazilian medicinal plant known as "wolf fruit," contains about 1.5% of glycoalkaloids in its dried fruits, consisting mainly of solamargine and solasonine. The present work reports the obtainment of the alkaloidic extract of the S. lycocarpum fruit by acid-base extraction and the isolation of the major alkaloid heterosides by chromatographic means, as well as the evaluation of their in vitro schistosomicidal activities. The in vitro schistosomicidal activities of the alkaloidic extract of S. lycocarpum fruits and its isolated steroidal alkaloids were undertaken against adult worms of Schistosoma mansoni. The alkaloidic extract (20, 32, and 50 μg mL(-1)), solasonine (50 μM), solamargine (32 and 50 μM), and equimolar mixture of glycoalkaloids (20, 32, and 50 μM) lead to the separation of all couple worms and extensive disruption on their teguments, such as sloughing, as well as their deaths within 24 h of incubation. In addition, the alkaloidic extract (10 and 15 μg mL(-1)), solasonine (50 μM), solamargine (10, 15, and 20 μM), and equimolar mixtures of glycoalkaloids (10 and 15 μM) reduced the development of eggs produced by the adult worms. Solamargine, containing the sugar chain moiety chacotriose, was more active than the solasonine, which contains solatriose sugar chain moiety. A synergistic effect was also observed for a mixture of solamargine and solasonine. Therefore, the alkaloidic extract of S. lycocarpum, and its major components, solamargine and solasonine, showed promising schistosomicidal activity.
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