ArticleInternational immunology2012
Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4.
Article in International immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- TSLP: contrasting roles in cancer.Frontiers in immunology · 2025Review
- Thymic Stromal Lymphopoietin Activates Mouse Dendritic Cells Through the JAK/SYK Pathway in Promoting Th17 Response in Psoriasis.Balkan medical journal · 2024Article
- B cell- and T cell-intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling.Science immunology · 2023Article
- Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion.Science (New York, N.Y.) · 2021Article
- Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer.Frontiers in immunology · 2020Review
- TSLP: from allergy to cancer.Nature immunology · 2019Review
- Functional analysis of a novel G87V TNFRSF1A mutation in patients with TNF receptor-associated periodic syndrome.Clinical and experimental immunology · 2019Article
- Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer.Frontiers in immunology · 2018Review
- Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.The Journal of experimental medicine · 2015Article
- Role of IL-4 gene polymorphisms in HBV-related hepatocellular carcinoma in a Chinese population.PloS one · 2014Article
- The biology of thymic stromal lymphopoietin (TSLP).Advances in pharmacology (San Diego, Calif.) · 2013Review
- Cytokines in chronic respiratory diseases.F1000 biology reports · 2013Article
- Regulation of inflammation by interleukin-4: a review of "alternatives".Journal of leukocyte biology · 2012Review
- The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond.Journal of leukocyte biology · 2012Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The cytokine thymic stromal lymphopoietin (TSLP) functions as a regulator of bone marrow B-cell development and a key initiator of allergic inflammation. In the current study, we show that mature B cells, derived from transgenic mice with systemically elevated levels of TSLP (K5-TSLP mice), exhibit markedly enhanced mitogenic responses in vitro and that this enhanced responsiveness leads to polyclonal B-cell activation and development of autoimmune hemolytic anemia in vivo. In contrast, B cells derived from K5-TSLP mice lacking CD4(+) T cells failed to show polyclonal activation. Furthermore, neither mature B-cell activation nor hemolytic anemia occurred in IL-4-deficient K5-TSLP mice. Consistent with these findings, activation of mature B cells occurred independently of B-cell intrinsic TSLP signals. Taken together, our results demonstrate that systemic alterations in TSLP, through induction of IL-4 from CD4(+) T cells and other cell types, functions as an important factor in peripheral B-cell homeostasis and promotion of humoral autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.