ArticleFEBS letters2012
Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans.
Article in FEBS letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Molecular profiling of adult C. elegans glia across sexes by single-nuclear RNA-seq.Developmental cell · 2025Article
- Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance.EMBO reports · 2020Article
- The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection.The Biochemical journal · 2017Review
- Article
- The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans.PloS one · 2016Article
- Delayed innocent bystander cell death following hypoxia in Caenorhabditis elegans.Cell death and differentiation · 2014Article
- An anoxia-starvation model for ischemia/reperfusion in C. elegans.Journal of visualized experiments : JoVE · 2014Article
- Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning.American journal of physiology. Heart and circulatory physiology · 2013Article
- Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.Biochimica et biophysica acta · 2013Review
- Bicarbonate modulates oxidative and functional damage in ischemia-reperfusion.Free radical biology & medicine · 2013Article
- SLO-2 isoforms with unique Ca(2+) - and voltage-dependence characteristics confer sensitivity to hypoxia in C. elegans.Channels (Austin, Tex.)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Hypoxic preconditioning (HP) is an evolutionarily-conserved mechanism that protects an organism against stress. The mitochondrial ATP-sensitive K(+) channel (mK(ATP)) plays an essential role in the protective signaling, but remains molecularly undefined. Several lines of evidence suggest that mK(ATP) may arise from an inward rectifying K(+) channel (Kir). The genetic model organism Caenorhabditis elegans exhibits HP and displays mK(ATP) activity. Here, we investigate the tissue expression profile of the three C. elegans Kir genes and demonstrate that mutant strains where the irk genes have been deleted either individually or in combination can be protected by HP and exhibit robust mK(ATP) channel activity in purified mitochondria. These data suggest that the mK(ATP) in C. elegans does not arise from a Kir derived channel.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.