ArticleActa veterinaria Scandinavica2012
Haemostatic alterations in a group of canine cancer patients are associated with cancer type and disease progression.
Article in Acta veterinaria Scandinavica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Biochemical and haemostatic variables associated with metastasis in dogs with carcinoma or sarcoma.The Journal of small animal practice · 2026Article
- Thromboembolic disease and hemostatic alterations in tumor-bearing dogs - A narrative review.Frontiers in veterinary science · 2026Review
- Comprehensive characterization of platelet function in dogs with hyperadrenocorticism.Haematologica · 2025Article
- Coagulation status of immune-mediated polyarthritis in dogs.The Journal of small animal practice · 2025Article
- Retrospective Study of Clinicopathological Changes and Prediction Model for Canine Vascular Neoplasms.Veterinary sciences · 2024Article
- An Evaluation of Hemostatic Dysregulation in Canine Multicentric Lymphoma.Animals : an open access journal from MDPI · 2024Article
- Paired Analysis of D-Dimer and Its Correlated Hemostatic Parameters in 30 Dogs with Neoplasms after Tumorectomy.Animals : an open access journal from MDPI · 2023Article
- Parameters of Metabolic Response to Surgical Trauma Induced via Unilateral Total Mastectomy Associated or Not to Ovariohysterectomy in Dogs.Animals : an open access journal from MDPI · 2023Article
- Coagulation Abnormalities in Dogs with Parvoviral Enteritis.Veterinary sciences · 2023Article
- Evaluation of Haemostasis in Dogs Affected by Resectable Malignancy.Animals : an open access journal from MDPI · 2022Article
- Pre-operative Hemostatic Status in Dogs Undergoing Splenectomy for Splenic Masses.Frontiers in veterinary science · 2022Article
- Outcome and treatments of dogs with aortic thrombosis: 100 cases (1997-2014).Journal of veterinary internal medicine · 2020Article
- Tissue factor procoagulant activity in the tumor cell lines and plasma of dogs with various malignant tumors.The Journal of veterinary medical science · 2019Article
- Evaluation of procoagulant tissue factor expression in canine hemangiosarcoma cell lines.American journal of veterinary research · 2017Article
- A review on the role of L-carnitine in the management of tamoxifen side effects in treated women with breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- Retrospective Characterization of Clot Waveform Analysis in Canine Immune-Mediated Hemolytic Anemia Using the Turbidimetric ACL-TOP 300 Analyzer (2018-2022): 35 Cases.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Article
- Increased plasma DR-70 (fibrinogen-fibrin degradation products) concentrations as a diagnostic biomarker in dogs with neoplasms.Journal of veterinary internal medicineArticle
- Anticoagulant effect of Huisheng Oral Solution in a rat model of thrombosis.Indian journal of pharmacologyArticle
- A prospective evaluation of the prevalence of thromboemboli and associated hemostatic dysfunction in dogs with carcinoma or sarcoma.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHaemostatic alterations are commonly detected in human and canine cancer patients. Previous studies have described haemostatic dysfunction in canine patients with haemangiosarcomas and carcinomas, and haemostasis has been assessed in dogs with various malignant and benign neoplasias. Few studies have addressed the effect of cancer type and progression of disease on the presence of haemostatic alterations in canine patients. The objective of the present study was to evaluate haemostatic variables of coagulation and fibrinolysis in a group of canine cancer patients, and to compare haemostatic changes to the cancer type and progression of disease.
methodsThe study population consisted of 71 dogs with malignant neoplasia presented to the University Hospital for Companion Animals, Faculty of Life Sciences, University of Copenhagen, Denmark. The study was designed as a prospective observational study evaluating the haemostatic function in canine cancer patients stratified according to type of cancer disease and disease progression. The coagulation response was evaluated by thromboelastrography (TEG), platelet count, activated partial thromboplastin time (aPTT), prothombin time (PT), fibrinogen and antithrombin (AT); and fibrinolysis by d-dimer and plasminogen.
resultsHypercoagulability was the most common haemostatic dysfunction found. Non mammary carcinomas had increased clot strength (TEG G), aPTT and fibrinogen compared to the other groups. When stratifying the patients according to disease progression dogs with distant metastatic disease exhibited significantly increased fibrinogen, and d-dimer compared to dogs with local invasive and local non-invasive cancers.
conclusionHypercoagulability was confirmed as the most common haemostatic abnormality in canine cancer patients and haemostatic dysfunction in canine cancer patients was found related to the cancer type and progression of disease. Increase in TEG G, aPTT and fibrinogen were observed in non-mammary carcinomas and were speculated to overall represent a proinflammatory response associated with the disease. Dogs with distant metastatic disease exhibited increased fibrinogen and d-dimer. Future studies are needed to elucidate the clinical importance of these results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.