ArticleJournal of the American Chemical Society2012
Total synthesis of the α-subunit of human glycoprotein hormones: toward fully synthetic homogeneous human follicle-stimulating hormone.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Advances in the chemical synthesis of human proteoforms.Science China. Life sciences · 2025Review
- Glycoconjugates: Synthesis, Functional Studies, and Therapeutic Developments.Chemical reviews · 2022Review
- Chemoenzymatic Semisynthesis of Proteins.Chemical reviews · 2020Review
- Cell-Free Synthetic Glycobiology: Designing and Engineering Glycomolecules Outside of Living Cells.Frontiers in chemistry · 2020Review
- Peptidyl ω-Asp Selenoesters Enable Efficient Synthesis ofFrontiers in chemistry · 2020Article
- Chemoenzymatic Synthesis of HIV-1 Glycopeptide Antigens.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Oligosaccharide Synthesis and Translational Innovation.Journal of the American Chemical Society · 2019Review
- Chemoenzymatic Methods for the Synthesis of Glycoproteins.Chemical reviews · 2018Review
- Total Chemical Synthesis of Human Thyroid-Stimulating Hormone (hTSH)Tetrahedron · 2018Article
- Sequence Diversification by Divergent C-Terminal Elongation of Peptides.The Journal of organic chemistry · 2018Article
- Total synthesis of glycosylated proteins.Topics in current chemistry · 2015Review
- Chemical synthesis of the β-subunit of human luteinizing (hLH) and chorionic gonadotropin (hCG) glycoprotein hormones.Journal of the American Chemical Society · 2014Article
- Rapid flow-based peptide synthesis.Chembiochem : a European journal of chemical biology · 2014Article
- Chemical and chemoenzymatic synthesis of glycoproteins for deciphering functions.Chemistry & biology · 2014Review
- Efficient, Traceless Semi-Synthesis of α-Synuclein Labeled with a Fluorophore/Thioamide FRET Pair.Synlett : accounts and rapid communications in synthetic organic chemistry · 2013Article
- The winding pathway to erythropoietin along the chemistry-biology frontier: a success at last.Angewandte Chemie (International ed. in English) · 2013Review
- Expressed protein ligation at methionine: N-terminal attachment of homocysteine, ligation, and masking.Angewandte Chemie (International ed. in English) · 2013Article
- An advance in the chemical synthesis of homogeneous N-linked glycopolypeptides by convergent aspartylation.Angewandte Chemie (International ed. in English) · 2012Article
- Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.Journal of the American Chemical Society · 2012Article
- Function and 3D structure of the N-glycans on glycoproteins.International journal of molecular sciences · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Described herein is the first total chemical synthesis of the unique α-subunit of the human glycoprotein hormone (α-hGPH). Unlike the biologically derived glycoprotein hormones, which are isolated as highly complex mixtures of glycoforms, α-hGPH obtained by chemical synthesis contains discrete homogeneous glycoforms. Two such systems have been prepared. One contains the disaccharide chitobiose at the natural N-glycosylation sites. The other contains dodecamer oligosaccharides at these same sites. The dodecamer sugar is a consensus sequence incorporating the key features associated with human glycoproteins.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.