ReviewCurrent drug targets2012
Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides.
Review in Current drug targets, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Plant derived biopesticides for controlling imported fire ants (Frontiers in plant science · 2026Review
- Exploration of bioactive molecules from Sesbania grandiflora (L.): identification of squalene as an effective compound against the two-spotted spider mite, Tetranychus urticae Koch, through molecular docking.Experimental & applied acarology · 2024Article
- Essential Oils of Two Subspecies ofMolecules (Basel, Switzerland) · 2024Article
- Discovery selective acetylcholinesterase inhibitors to control Tetranychus urticae (Acari: Tetranychidae).Journal of insect science (Online) · 2023Article
- Essential Oils for a Sustainable Control of Honeybee Varroosis.Veterinary sciences · 2023Review
- Biopesticides as a promising alternative to synthetic pesticides: A case for microbial pesticides, phytopesticides, and nanobiopesticides.Frontiers in microbiology · 2023Review
- Synthesis and Biological Studies of Novel Aminophosphonates and Their Metal Carbonyl Complexes (Fe, Ru).International journal of molecular sciences · 2022Article
- Sequence variation and regulatory variation in acetylcholinesterase genes contribute to insecticide resistance in different populations ofEcology and evolution · 2021Article
- New carvacrol and thymol derivatives as potential insecticides: synthesis, biological activity, computational studies and nanoencapsulation.RSC advances · 2021Article
- Synergistic Field Crop Pest Management Properties of Plant-Derived Essential Oils in Combination with Synthetic Pesticides and Bioactive Molecules: A Review.Foods (Basel, Switzerland) · 2021Review
- Acaricidal, Insecticidal, and Nematicidal Efficiency of Essential Oils Isolated from theInternational journal of environmental research and public health · 2021Review
- Acetylcholinesterase target sites for developing environmentally friendly insecticides against Tetranychus urticae (Acari: Tetranychidae).Experimental & applied acarology · 2021Article
- In Silico Studies of Lamiaceae Diterpenes with Bioinsecticide Potential againstMolecules (Basel, Switzerland) · 2021Article
- Cysteine-Targeted Insecticides againstACS medicinal chemistry letters · 2020Article
- Article
- Assessment of acute toxicity and cytotoxicity of fluorescent markers produced by cardanol and glycerol, which are industrial waste, to different biological models.Environmental science and pollution research international · 2019Article
- Acaricidal effect of Schinus molle (Anacardiaceae) essential oil on unengorged larvae and engorged adult females of Rhipicephalus sanguineus (Acari: Ixodidae).Experimental & applied acarology · 2018Article
- In Silico Studies on Compounds Derived fromBiomolecules · 2018Article
- Molecular Targets for Components of Essential Oils in the Insect Nervous System-A Review.Molecules (Basel, Switzerland) · 2017Review
- The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors.Memorias do Instituto Oswaldo Cruz · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insect pests are responsible for human suffering and financial losses worldwide. New and environmentally safe insecticides are urgently needed to cope with these serious problems. Resistance to current insecticides has resulted in a resurgence of insect pests, and growing concerns about insecticide toxicity to humans discourage the use of insecticides for pest control. The small market for insecticides has hampered insecticide development; however, advances in genomics and structural genomics offer new opportunities to develop insecticides that are less dependent on the insecticide market. This review summarizes the literature data that support the hypothesis that an insect-specific cysteine residue located at the opening of the acetylcholinesterase active site is a promising target site for developing new insecticides with reduced off-target toxicity and low propensity for insect resistance. These data are used to discuss the differences between targeting the insect-specific cysteine residue and targeting the ubiquitous catalytic serine residue of acetylcholinesterase from the perspective of reducing off-target toxicity and insect resistance. Also discussed is the prospect of developing cysteine-targeting anticholinesterases as effective and environmentally safe insecticides for control of disease vectors, crop damage, and residential insect pests within the financial confines of the present insecticide market.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.