ReviewRecent patents on CNS drug discovery2012
Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives.
Review in Recent patents on CNS drug discovery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04878627 (The Role of Cannabidiol in Regulating Meal Time Anxiety in Anorexia Nervous), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Cannabidiol in Regulating Meal Time Anxiety in Anorexia Nervous: Safety, Tolerability and Pharmacokinetics
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Cannabis, a cause for anxiety? A critical appraisal of the anxiogenic and anxiolytic properties.Journal of translational medicine · 2020Pooled it
- Medical and non-medical marijuana use in depression: Longitudinal associations with suicidal ideation, everyday functioning, and psychiatry service utilization.Journal of affective disorders · 2018Trial
- A Cross-Sectional Survey of Cannabis Use and Utility Among Patients Experiencing Dizziness.Brain sciences · 2026Article
- The Effects ofPharmaceuticals (Basel, Switzerland) · 2025Article
- The Complex Relationship Between Cannabis Use and Mental Health: Considering the Influence of Cannabis Use Patterns and Individual Factors.CNS drugs · 2025Review
- Pharmacotherapeutic strategies for the treatment of anorexia nervosa - novel targets to break a vicious cycle.Expert opinion on pharmacotherapy · 2024Review
- Modulation of CB1 cannabinoid receptor alters the electrophysiological properties of cerebellar Purkinje cells in harmaline-induced essential tremor.IBRO neuroscience reports · 2024Article
- Innovative and Emerging Treatments for Anorexia Nervosa.Focus (American Psychiatric Publishing) · 2024Article
- Anandamide Attenuates Neurobehavioral Deficits and EEG Irregularities in the Chronic Sleep Deprivation Rats: The Role of Oxidative Stress and Neuroinflammation.Neurochemical research · 2024Article
- Effects of cannabidiol, with and without ∆9-tetrahydrocannabinol, on anxiety-like behavior following alcohol withdrawal in mice.Frontiers in neuroscience · 2024Article
- Amphetamine-type stimulant (ATS) use and association with concurrent use of benzodiazepines, barbiturates and THC in the West Bank among male Palestinians: a cross-sectional study.BMJ public health · 2023Article
- Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge.Frontiers in veterinary science · 2023Review
- Observational
- Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects.Psychopharmacology · 2022Article
- Cannabidiol as a personalized treatment for anxiety: clinical cases in Mexico.Drugs in context · 2022Article
- [Hospital epidemiology of psychiatric disorders in Mali].The Pan African medical journal · 2022Article
- Cannabis Legalization and College Mental Health.Current psychiatry reports · 2021Review
- Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development.Journal of medicinal chemistry · 2021Review
- The effectiveness of inhaled Cannabis flower for the treatment of agitation/irritability, anxiety, and common stress.Journal of cannabis research · 2020Article
- Cannabis use, problem-gambling severity, and psychiatric disorders: Data from the National Epidemiological Survey on Alcohol and Related Conditions.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Rich evidence has shown that cannabis products exert a broad gamut of effects on emotional regulation. The main psychoactive ingredient of hemp, Δ9-tetrahydrocannabinol (THC), and its synthetic cannabinoid analogs have been reported to either attenuate or exacerbate anxiety and fear-related behaviors in humans and experimental animals. The heterogeneity of cannabis-induced psychological outcomes reflects a complex network of molecular interactions between the key neurobiological substrates of anxiety and fear and the endogenous cannabinoid system, mainly consisting of the arachidonic acid derivatives anandamide and 2-arachidonoylglycerol (2-AG) and two receptors, respectively termed CB1 and CB2. The high degree of interindividual variability in the responses to cannabis is contributed by a wide spectrum of factors, including genetic and environmental determinants, as well as differences in the relative concentrations of THC and other alkaloids (such as cannabidiol) within the plant itself. The present article reviews the currently available knowledge on the herbal, synthetic and endogenous cannabinoids with respect to the modulation of anxiety responses, and highlights the challenges that should be overcome to harness the therapeutic potential of some of these compounds, all the while limiting the side effects associated with cannabis consumption. In addition the article presents some promising patents on cannabinoid-related agents.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.