ArticleCNS neuroscience & therapeutics2012
A neuroprotective mechanism of YGY-E in cerebral ischemic injury in rats.
Article in CNS neuroscience & therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- MicroRNA target gene prediction of ischemic stroke by using variational Bayesian inference for Gauss mixture model.Experimental and therapeutic medicine · 2019Article
- miR-455 inhibits neuronal cell death by targeting TRAF3 in cerebral ischemic stroke.Neuropsychiatric disease and treatment · 2016Article
- MicroRNA-124 protects neurons against apoptosis in cerebral ischemic stroke.CNS neuroscience & therapeutics · 2013Article
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Authors and funding
7 authors.
Funding
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Abstract
aimsTo investigate the anticerebral ischemic properties of YGY-E (apigenin-7-O-β-D-glucopyranosy l-4'-O-α-L-rhamnopy-ranosid, a flavonoid glycoside extracted from plant phoenix-tail fern), focusing on its effects on neuronal apoptosis.
methodsIn vitro YGY-E treatment was examined in primary cultured rat hippocampal neurons subjected to hypoxia-reoxygenation (H-R) injury. In addition, in vivo effects of YGY-E on neuronal apoptosis were measured by Hoechst staining and in situ DNA end labeling (TUNEL). Finally, B cell lymphoma/lewkmia-2 (Bcl-2) level in ischemic rat brain tissue was evaluated with immunohistochemistry and western blot analyses.
resultsIn vitro YGY-E (50-100 μg/mL) treatment increased the survival rate compared to that of the vehicle-treated group (P < 0.05 and P < 0.01, respectively). In in vivo experiments, YGY-E (2.5-10 mg/kg) decreased the percentage of apoptotic neurons (P < 0.01), increased Bcl-2 (P < 0.01) in ischemic rat brain tissue. These effects were dose dependent.
conclusionsOur findings indicate that YGY-E's neuroprotective effects may be because of its inhibition of neuronal apoptosis by increasing Bcl-2 expression.
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