ArticlePloS one2012
Proteomes and signalling pathways of antler stem cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Insights into the molecular characteristics of embryonic cranial neural crest cells and their derived mesenchymal cell pools.Communications biology · 2024Article
- Amputation Triggers Long-Range Epidermal Permeability Changes in Evolutionarily Distant Regenerative Organisms.bioRxiv : the preprint server for biology · 2024Article
- The characteristics and medical applications of antler stem cells.Stem cell research & therapy · 2023Review
- HGF/c-Met signaling promotes the migration and proliferation of deer antler MSCs.Scientific reports · 2023Article
- Galectin-1 promotes angiogenesis and chondrogenesis during antler regeneration.Cellular & molecular biology letters · 2023Article
- The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation.Genomics, proteomics & bioinformatics · 2023Article
- Single-cell transcriptome reveals core cell populations and androgen-RXFP2 axis involved in deer antler full regeneration.Cell regeneration (London, England) · 2022Article
- Article
- MAPK/ERK Pathway as a Central Regulator in Vertebrate Organ Regeneration.International journal of molecular sciences · 2022Review
- Calreticulin Identified as One of the Androgen Response Genes That Trigger Full Regeneration of the Only Capable Mammalian Organ, the Deer Antler.Frontiers in cell and developmental biology · 2022Article
- RNA sequencing-based identification of microRNAs in the antler cartilage of Gansu red deer (PeerJ · 2022Article
- Cross-Species Analysis Reveals Co-Expressed Genes Regulating Antler Development in Cervidae.Frontiers in genetics · 2022Article
- The periosteum: a simple tissue with many faces, with special reference to the antler-lineage periostea.Biology direct · 2021Review
- Antler stem cells and their potential in wound healing and bone regeneration.World journal of stem cells · 2021Review
- New physiological insights into the phenomena of deer antler: A unique model for skeletal tissue regeneration.Journal of orthopaedic translation · 2021Review
- Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway.Stem cells international · 2020Article
- Single-cell transcriptome provides novel insights into antler stem cells, a cell type capable of mammalian organ regeneration.Functional & integrative genomics · 2019Article
- Full-length transcriptome and microRNA sequencing reveal the specific gene-regulation network of velvet antler in sika deer with extremely different velvet antler weight.Molecular genetics and genomics : MGG · 2019Article
- Transcriptomic analysis of different tissue layers in antler growth Center in Sika Deer (Cervus nippon).BMC genomics · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the only known example of complete organ regeneration in mammals, deer antler in the growing or velvet phase is of major interest in developmental biology. This regeneration event initiates from self-renewing antler stem cells that exhibit pluripotency. At present, it remains unclear how the activation and quiescence of antler stem cells are regulated. Therefore, in the present study proteins that were differentially expressed between the antler stem cells and somatic cells (facial periosteum) were identified by a gel-based proteomic technique, and analysed using Ingenuity Pathway Analysis software. Several molecular pathways (PI3K/Akt, ERK/MAPK, p38 MAPK, etc.) were found to be activated during proliferation. Also expressed were the transcription factors POU5F1, SOX2, NANOG and MYC, which are key markers of embryonic stem cells. Expression of these proteins was confirmed in both cultured cells and fresh tissues by Western blot analysis. Therefore, the molecular pathways and transcription factors identified in the current study are common to embryonic and adult stem cells. However, expression of embryonic stem cell transcription factors would suggest that antler stem cells are, potentially, an intermediary stem cell type between embryonic and the more specialized tissue-specific stem cells like those residing in muscle, fat or from a hematopoietic origin. The retention of this embryonic, pluripotent lineage may be of fundamental importance for the subsequent regenerative capacity of antlers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.