ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2011
Health-related quality of life and disease activity in rheumatoid arthritis.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Depression, Anxiety, and Health-Related Quality of Life in Adults with Rheumatoid Arthritis: Findings from a National Survey.Journal of clinical medicine · 2025Article
- Interleukin-6 in synovial fluid drives the conversion of DC2s to DC3s in inflammatory arthritis.iScience · 2025Article
- Multiscale, mechanistic model of Rheumatoid Arthritis to enable decision making in late stage drug development.NPJ systems biology and applications · 2024Article
- Factors affecting quality of life in patients with rheumatoid arthritis in South Korea: a cross-sectional study.Clinical rheumatology · 2022Article
- C-reactive protein as an available biomarker determining mental component of health-related quality of life among individuals with spinal cord injury.The journal of spinal cord medicine · 2017Article
- SF-36 total score as a single measure of health-related quality of life: Scoping review.SAGE open medicine · 2016Article
- Cross-Country Differences in the Additive Effects of Socioeconomics, Health Behaviors and Medical Comorbidities on Disability among Older Adults with Heart Disease.The journal of Tehran Heart Center · 2015Article
- Depression Mediates the Effect of Sexual Function on Quality of Life among Men but Not Women with Coronary Artery Disease.International cardiovascular research journal · 2014Article
- Mental health status of women with rheumatoid arthritis in iran.Iranian Red Crescent medical journal · 2014Article
- Comorbidity influences multiple aspects of well-being of patients with ischemic heart disease.International cardiovascular research journal · 2013Article
- Predictors and effective factors on quality of life among Iranian patients with rheumatoid arthritis.Materia socio-medica · 2013Article
- Quality of life among Iranian patients with beta-thalassemia major using the SF-36 questionnaire.Sao Paulo medical journal = Revista paulista de medicina · 2013Article
- Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70.Biologics : targets & therapy · 2012Article
- Symptoms of anxiety and depression: A comparison among patients with different chronic conditions.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2011Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study sought to 1) investigate the degrees of correlations between different disease activity scores (DASs) and health-related quality of life (HRQoL), and 2) determine if DASs correlate with either physical or mental HRQoL.
methodsEighty patients with rheumatoid arthritis (RA) were assessed for different DASs, measured with erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP), namely DAS4-ESR, DAS-3 ESR, DAS4-CRP, DAS3-CRP, DAS4-28 ESR, DAS3-28 ESR, DAS4-28 CRP, and DAS3-28 CRP, and Simplified Disease Activity Indexes namely SDAI-ESR, and SDAI-CRP. Physical and mental HRQoL were measured using the SF-36. The Pearson correlation test was employed to examine the correlations between HRQoL and different DAS indices. PASS 2000 (Power Analysis and Sample Size) software was utilized to find significant differences between the correlations.
resultsSF-36 total score showed a significant inverse correlation with the DAS4-ESR, DAS-3 ESR, DAS4-CRP, DAS3-CRP, DAS4-28 ESR, DAS3-28 ESR, DAS4-28 CRP, and DAS3-28 CRP, with correlation coefficients of -0.320, -0.314, -0.330, -0.323, -0.327, -0.318, -0.360 and -0.348, respectively (P < 0.01 for all). The correlation coefficients between different DAS indices and the HRQoL score were not significantly different. In addition, all DASs showed significant correlations with physical HRQoL, but not with mental HRQoL.
conclusionsAmong patients with RA, disease severity indices are associated with physical, but not mental HRQoL. However this study failed to show any differences between various DASs in their clinical use.
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