ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
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- Global Proteome Profiling of the Temporal Cortex of Female Rats Exposed to Chronic Stress and the Western Diet.Nutrients · 2022Article
- Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.International journal of molecular sciences · 2022Article
- Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Histone deacetylase-3: Friend and foe of the brain.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells.Particle and fibre toxicology · 2020Article
- Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.Frontiers in immunology · 2020Article
- Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease.Neurobiology of disease · 2018Article
- The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding.Human reproduction update · 2016Review
- Neuronal pentraxin 1 negatively regulates excitatory synapse density and synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Genetic deletion of neuronal pentraxin 1 expression prevents brain injury in a neonatal mouse model of cerebral hypoxia-ischemia.Neurobiology of disease · 2015Article
- A New Experimental Model for Neuronal and Glial Differentiation Using Stem Cells Derived from Human Exfoliated Deciduous Teeth.Journal of molecular neuroscience : MN · 2013Article
- Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1.Neural regeneration research · 2013Article
- Critical role of neuronal pentraxin 1 in mitochondria-mediated hypoxic-ischemic neuronal injury.Neurobiology of disease · 2013Article
- Alleviation of neuropathic pain hypersensitivity by inhibiting neuronal pentraxin 1 in the rostral ventromedial medulla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In cultured cerebellar granule neurons, low neuronal activity triggers the intrinsic program of apoptosis, which requires protein synthesis-dependent BAX translocation to mitochondria, a process that may underlie neuronal damage in neurodegeneration. However, the mechanisms that link neuronal activity with the induction of the mitochondrial program of apoptosis remain unclear. Neuronal pentraxin 1 (NP1) is a pro-apoptotic protein induced by low neuronal activity that is increased in damaged neurites in Alzheimer's disease-affected brains. Here we report that NP1 facilitates the accumulation of BAX in mitochondria and regulates mitochondrial dynamics during apoptosis in rat and mouse cerebellar granule neurons in culture. Reduction of neuronal activity increases NP1 protein levels in mitochondria and contributes to mitochondrial fragmentation in a Bax-dependent manner. In addition, NP1 is involved in mitochondrial transport in healthy neurons. These results show that NP1 is targeted to mitochondria acting upstream of BAX and uncover a novel function for NP1 in the regulation of mitochondrial dynamics and trafficking during apoptotic neurodegeneration.
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