Trial reportJournal of neurophysiology2012
Robustness of muscle synergies underlying three-dimensional force generation at the hand in healthy humans.
Trial report in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06523335 (Intermuscular Coordination as a Novel Clinical Target for Stroke Neurorehabilitation), which is not on this map. Cited by 74 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intermuscular Coordination as a Novel Clinical Target for Stroke Neurorehabilitation
Who cites it
74 citing papers in PubMed, 145 citations in OpenAlex.
- Myoelectric interface training enables targeted reduction in abnormal muscle co-activation.Journal of neuroengineering and rehabilitation · 2022Trial
- Effects of squat load and velocity on neuromuscular control strategies.European journal of applied physiology · 2026Article
- Changes in synergy formation and modulation during cyclic finger force production tasks in female adults with dystonic cerebral palsy.Experimental brain research · 2026Article
- A dataset for bilateral lower limb muscle synergy patterns in unilateral anterior cruciate ligament reconstructed patients.Scientific data · 2026Article
- Relationship between lower limb muscle coordination and knee flexion angle during the swing phase of gait in post-stroke individuals.Journal of neuroengineering and rehabilitation · 2026Article
- Generalizability of neuromuscular coordination in the human upper extremity after stroke and its implications in neurorehabilitation.Journal of neuroengineering and rehabilitation · 2025Article
- Sensor-assessed grasping time as a biomarker of functional impairment in rheumatoid arthritis.Scientific reports · 2025Article
- Electro-tactile modulation of muscle activation and intermuscular coordination in the human upper extremity.Scientific reports · 2025Article
- Hypergravity is more challenging than microgravity for the human sensorimotor system.NPJ microgravity · 2025Article
- Investigating the impact of external load on muscle synergies during bipedal squats.European journal of applied physiology · 2024Article
- Synergy quality assessment of muscle modules for determining learning performance using a realistic musculoskeletal model.Frontiers in computational neuroscience · 2024Article
- Muscle synergies are associated with intermuscular coherence and cortico-synergy coherence in an isometric upper limb task.Experimental brain research · 2023Article
- Developing new intermuscular coordination patterns through an electromyographic signal-guided training in the upper extremity.Journal of neuroengineering and rehabilitation · 2023Article
- Muscle synergies for evaluating upper limb in clinical applications: A systematic review.Heliyon · 2023Review
- Neuromuscular control: from a biomechanist's perspective.Frontiers in sports and active living · 2023Review
- Muscle synergies in joystick manipulation.Frontiers in physiology · 2023Article
- Heavier Load Alters Upper Limb Muscle Synergy with Correlated fNIRS Responses in BA4 and BA6.Cyborg and bionic systems (Washington, D.C.) · 2023Article
- Generalizability of muscle synergies in isometric force generation versus point-to-point reaching in the human upper extremity workspace.Frontiers in human neuroscience · 2023Article
- The effect of limb position on a static knee extension task can be explained with a simple spinal cord circuit model.Journal of neurophysiology · 2022Article
- Abnormal proximal-distal interactions in upper-limb of stroke survivors during object manipulation: A pilot study.Frontiers in human neuroscience · 2022Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies using advanced matrix factorization techniques have shown that the coordination of human voluntary limb movements may be accomplished using combinations of a small number of intermuscular coordination patterns, or muscle synergies. However, the potential use of muscle synergies for isometric force generation has been evaluated mostly using correlational methods. The results of such studies suggest that fixed relationships between the activations of pairs of muscles are relatively rare. There is also emerging evidence that the nervous system uses independent strategies to control movement and force generation, which suggests that one cannot conclude a priori that isometric force generation is accomplished by combining muscle synergies, as shown in movement control. In this study, we used non-negative matrix factorization to evaluate the ability of a few muscle synergies to reconstruct the activation patterns of human arm muscles underlying the generation of three-dimensional (3-D) isometric forces at the hand. Surface electromyographic (EMG) data were recorded from eight key elbow and shoulder muscles during 3-D force target-matching protocols performed across a range of load levels and hand positions. Four synergies were sufficient to explain, on average, 95% of the variance in EMG datasets. Furthermore, we found that muscle synergy composition was conserved across biomechanical task conditions, experimental protocols, and subjects. Our findings are consistent with the view that the nervous system can generate isometric forces by assembling a combination of a small number of muscle synergies, differentially weighted according to task constraints.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.