ArticleBMJ (Clinical research ed.)2012
25 year trends in first time hospitalisation for acute myocardial infarction, subsequent short and long term mortality, and the prognostic impact of sex and comorbidity: a Danish nationwide cohort study.
Article in BMJ (Clinical research ed.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
182 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- The global prevalence of myocardial infarction: a systematic review and meta-analysis.BMC cardiovascular disorders · 2023Pooled it
- Beta-blockers in patients without heart failure after myocardial infarction.The Cochrane database of systematic reviews · 2021Pooled it
- Beta-blockers for suspected or diagnosed acute myocardial infarction.The Cochrane database of systematic reviews · 2019Pooled it
- Factors influencing harmonized health data collection, sharing and linkage in Denmark and Switzerland: A systematic review.PloS one · 2019Pooled it
- Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection.Basic research in cardiology · 2018Guideline
- Drug-eluting stents versus bare-metal stents for acute coronary syndrome.The Cochrane database of systematic reviews · 2017Pooled it
- Oxygen therapy for acute myocardial infarction.The Cochrane database of systematic reviews · 2016Pooled it
- Under-reporting of venous and arterial thrombotic events in randomized clinical trials: a meta-analysis.Internal and emergency medicine · 2015Pooled it
- Trial
- Antecedent hypertension and myocardial injury in patients with reperfused ST-elevation myocardial infarction.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2016Trial
- Trial
- Bidirectional associations between anxiety disorders and myocardial infarction: a retrospective longitudinal cohort study.BMC cardiovascular disorders · 2026Article
- Incidence of Acute Myocardial Infarction in Hungary: A Nationwide Study.Journal of clinical medicine · 2026Article
- Trends in mortality and major adverse cardiovascular events following incident acute myocardial infarction.BMC cardiovascular disorders · 2026Article
- Association between door-to-wire time and 30-day mortality after PCI in patients with acute myocardial infarction: evidence from a single-center study in the China chest pain center registry.Frontiers in cardiovascular medicine · 2026Article
- Integrated left ventricular geometry-function phenotypes and long-term outcomes after acute myocardial infarction.Frontiers in cardiovascular medicine · 2026Article
- New Zealand Electronic Health Data for Cardiovascular Research: A Review.Clinical epidemiology · 2026Review
- Machine learning-based mortality risk prediction model for elderly diabetic patients with non-ST-segment elevation myocardial infarction using MIMIC-IV database.Scientific reports · 2025Article
- Care and outcomes of first-time myocardial infarction among vulnerable populations in Denmark, 2003-22: a nationwide registry-based cohort study.The Lancet regional health. Europe · 2025Article
- Looking Back, Leaning Forward-A Contemporary Overview of Acute Coronary Syndrome.Journal of clinical medicine · 2024Article
122 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine 25 year trends in first time hospitalisation for acute myocardial infarction in Denmark, subsequent short and long term mortality, and the prognostic impact of sex and comorbidity.
designNationwide population based cohort study using medical registries.
settingAll hospitals in Denmark. SUBJECTS: 234,331 patients with a first time hospitalisation for myocardial infarction from 1984 through 2008.
main outcome measuresStandardised incidence rate of myocardial infarction and 30 day and 31-365 day mortality by sex. Comorbidity categories were defined as normal, moderate, severe, and very severe according to the Charlson comorbidity index, and were compared by means of mortality rate ratios based on Cox regression.
resultsThe standardised incidence rate per 100,000 people decreased in the 25 year period by 37% for women (from 209 to 131) and by 48% for men (from 410 to 213). The 30 day, 31-365 day, and one year mortality declined from 31.4%, 15.6%, and 42.1% in 1984-8 to 14.8%, 11.1%, and 24.2% in 2004-8, respectively. After adjustment for age at time of myocardial infarction, men and women had the same one year risk of dying. The mortality reduction was independent of comorbidity category. Comparing patients with very severe versus normal comorbidity during 2004-8, the mortality rate ratio, adjusted for age and sex, was 1.96 (95% CI 1.83 to 2.11) within 30 days and 3.89 (3.58 to 4.24) within 31-365 days.
conclusionsThe rate of first time hospitalisation for myocardial infarction and subsequent short term mortality both declined by nearly half between 1984 and 2008. The reduction in mortality occurred for all patients, independent of sex and comorbidity. However, comorbidity burden was a strong prognostic factor for short and long term mortality, while sex was not.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.