ArticleDevelopment (Cambridge, England)2012
The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Rapgef1 paralog-mediated regulation of Wnt/β-catenin signaling orchestrates early embryo tissue patterning and morphogenesis.Cell communication and signaling : CCS · 2026Article
- Evolvability in vertebrate segmentation.Seminars in cell & developmental biology · 2025Review
- The vertebrate segmentation clock drives segmentation by stabilizing Dusp phosphatases in zebrafish.Developmental cell · 2025Article
- Temporal and Spatial Variations in ZebrafishInternational journal of molecular sciences · 2024Article
- Spatiotemporal control of pattern formation during somitogenesis.Science advances · 2024Review
- Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes.Nature communications · 2023Article
- Species-specific roles of the Notch ligands, receptors, and targets orchestrating the signaling landscape of the segmentation clock.Frontiers in cell and developmental biology · 2023Review
- Gene copy number and negative feedback differentially regulate transcriptional variability of segmentation clock genes.iScience · 2022Article
- The vertebrate Embryo Clock: Common players dancing to a different beat.Frontiers in cell and developmental biology · 2022Review
- Integrin intra-heterodimer affinity inversely correlates with integrin activatability.Cell reports · 2021Article
- Time and space in segmentation.Interface focus · 2021Article
- From local resynchronization to global pattern recovery in the zebrafish segmentation clock.eLife · 2021Article
- Small molecule screen in embryonic zebrafish using modular variations to target segmentation.Nature communications · 2017Article
- Delta-Notch signalling in segmentation.Arthropod structure & development · 2017Review
- Quadruple zebrafish mutant reveals different roles of Mesp genes in somite segmentation between mouse and zebrafish.Development (Cambridge, England) · 2016Article
- Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock.eLife · 2016Article
- Timing by rhythms: Daily clocks and developmental rulers.Development, growth & differentiation · 2016Review
- Stochastic Regulation of her1/7 Gene Expression Is the Source of Noise in the Zebrafish Somite Clock Counteracted by Notch Signalling.PLoS computational biology · 2015Article
- Spatial gradients of protein-level time delays set the pace of the traveling segmentation clock waves.Development (Cambridge, England) · 2014Article
- Signalling dynamics in vertebrate segmentation.Nature reviews. Molecular cell biology · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Using in vitro and in vivo assays, we define a network of Her/Hes dimers underlying transcriptional negative feedback within the zebrafish segmentation clock. Some of the dimers do not appear to be DNA-binding, whereas those dimers that do interact with DNA have distinct preferences for cis regulatory sequences. Dimerization is specific, with Hes6 serving as the hub of the network. Her1 binds DNA only as a homodimer but will also dimerize with Hes6. Her12 and Her15 bind DNA both as homodimers and as heterodimers with Hes6. Her7 dimerizes strongly with Hes6 and weakly with Her15. This network structure engenders specific network dynamics and imparts greater influence to the Her7 node. Computational analysis supports the hypothesis that Her7 disproportionately influences the availability of Hes6 to heterodimerize with other Her proteins. Genetic experiments suggest that this regulation is important for operation of the network. Her7 therefore has two functions within the zebrafish segmentation clock. Her7 acts directly within the delayed negative feedback as a DNA-binding heterodimer with Hes6. Her7 also has an emergent function, independent of DNA binding, in which it modulates network topology via sequestration of the network hub.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.