ArticleDevelopment (Cambridge, England)2012
Dusky-like functions as a Rab11 effector for the deposition of cuticle during Drosophila bristle development.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Article
- Mechanical control of the insect extracellular matrix nanostructure.Science advances · 2026Article
- Apical cell expansion maintained by Dusky-like establishes a scaffold for corneal lens morphogenesis.Science advances · 2024Article
- Role of BicDR in bristle shaft construction and support of BicD functions.Journal of cell science · 2024Article
- Article
- Dusky-like Is Critical for Morphogenesis of the Cellular Protuberances and Formation of the Cuticle inBiology · 2023Article
- Scale-type-specific requirement for the mosquito Aedes aegypti Spindle-F homologue by regulating microtubule organization.Insect molecular biology · 2022Article
- A Tale of Two Transcriptomic Responses in Agricultural Pests via Host Defenses and Viral Replication.International journal of molecular sciences · 2021Article
- Mutations in Drosophila crinkled/Myosin VIIA disrupt denticle morphogenesis.Developmental biology · 2021Article
- Article
- The first complete genomes of Metalmarks and the classification of butterfly families.Genomics · 2017Article
- Transcriptome profiling of ontogeny in the acridid grasshopper Chorthippus biguttulus.PloS one · 2017Article
- Seasonal phenotype-specific transcriptional reprogramming during metamorphosis in the European map butterflyEcology and evolution · 2016Article
- The Gene Expression Program for the Formation of Wing Cuticle in Drosophila.PLoS genetics · 2016Article
- Dusky-like is required for epidermal pigmentation and metamorphosis in Tribolium castaneum.Scientific reports · 2016Article
- ChtVis-Tomato, a genetic reporter for in vivo visualization of chitin deposition in Drosophila.Development (Cambridge, England) · 2015Article
- Nano-architecture of gustatory chemosensory bristles and trachea in Drosophila wings.Scientific reports · 2015Article
- The Drosophila planar polarity gene multiple wing hairs directly regulates the actin cytoskeleton.Development (Cambridge, England) · 2015Article
- The diaphanous gene of Drosophila interacts antagonistically with multiple wing hairs and plays a key role in wing hair morphogenesis.PloS one · 2015Article
- Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi.Development (Cambridge, England) · 2013Article
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2 authors.
Funding
Abstract
The morphogenesis of Drosophila sensory bristles is dependent on the function of their actin and microtubule cytoskeleton. Actin filaments are important for bristle shape and elongation, while microtubules are thought to mediate protein and membrane trafficking to promote growth. We have identified an essential role for the bristle cuticle in the maintenance of bristle structure and shape at late stages of bristle development. We show that the small GTPase Rab11 mediates the organized deposition of chitin, a major cuticle component in bristles, and disrupting Rab11 function leads to phenotypes that result from bristle collapse rather than a failure to elongate. We further establish that Rab11 is required for the plasma membrane localization of the ZP domain-containing Dusky-like (Dyl) protein and that Dyl is also required for cuticle formation in bristles. Our data argue that Dyl functions as a Rab11 effector for mediating the attachment of the bristle cell membrane to chitin to establish a stable cuticle. Our studies also implicate the exocyst as a Rab11 effector in this process and that Rab11 trafficking along the bristle shaft is mediated by microtubules.
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