Evidence map›Paper›PMID 22278716›Full record

ArticleDalton transactions (Cambridge, England : 2003)2012

Coordination-driven self-assembly of ruthenium-based molecular-rectangles: synthesis, characterization, photo-physical and anticancer potency studies.

Vaishali Vajpayee, Young Ho Song, Young Jun Jung, Se Chan Kang, Hyunuk Kim, In Su Kim, Ming Wang, Timothy R Cook, Peter J Stang, Ki-Whan Chi

Abstract read
In one paragraph

Article in Dalton transactions (Cambridge, England : 2003), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. In vivo anticancer activity of rhomboidal Pt(II) metallacycles.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vaishali VajpayeeDepartment of Chemistry, University of Ulsan, Ulsan, Republic of Korea.
Young Ho Song
Young Jun Jung
Se Chan Kang
Hyunuk Kim
In Su Kim
Ming Wang
Timothy R Cook
Peter J Stang
Ki-Whan Chi

Funding

POLYVALENT IODINE AND DERIVED CHEMISTRYR01GM057052 · NIGMS · UNIVERSITY OF UTAH · PI STANG, PETER J · 1998 to 2012
$3.3M
NIGMS NIH HHS GM-57052NIGMS NIH HHS R01 GM057052
6 · The paper itself

Abstract

A suite of eight cationic, tetra-metallic molecular rectangles (1-8) was generated via coordination-driven self-assembly using four dicarboxylate-bridged arene-Ru precursors (A1-A4) with one of two dipyridyl ligands (D1, D2). The high-yielding (84-92%) rectangles were characterized by (1)H NMR and HR-ESI-MS to support their structural assignments. The molecular structure of 5 was determined by single crystal X-ray analysis, which indicated that two D2 ligands bridge two A1 acceptors to form a rectangular construct. The photophysical properties of these metalla-rectangles and their molecular precursors were also investigated, as well as an MTT assay to evaluate the in vitro cytotoxicities relative to two chemotherapeutic agents, cisplatin and doxorubicin. MTT assays were conducted using SK-hep-1 (liver cancer) and HCT-15 (colon cancer) human cancer cell lines. Compounds 3, 4, 7 and 8 showed significant activity, with IC(50) values comparable to those of cisplatin and doxorubicin.

Indexed as

Antineoplastic AgentsCell Line, TumorElectronsHumansInhibitory Concentration 50Models, MolecularMolecular ConformationOrganometallic CompoundsRutheniumSpectrometry, FluorescenceSpectrophotometry, UltravioletAntineoplastic AgentsOrganometallic CompoundsRuthenium

Identifiers

PMID22278716
PMCPMC3437751

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.