ArticleThe ISME journal2012
Expression of the blood-group-related glycosyltransferase B4galnt2 influences the intestinal microbiota in mice.
Article in The ISME journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 65 citations in OpenAlex.
- Host genetics shapes the recovery of the gut microbiome after antibiotic treatment: the role of the blood group relatedmSystems · 2026Article
- Food hydrocolloids κ-carrageenan and xanthan gum in processed red meat modify gut health in rats.Current research in food science · 2025Article
- Rheinheimera faecalis sp. nov., isolated from Ceratotherium simum feces.Archives of microbiology · 2023Article
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- Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.The Journal of experimental medicine · 2023Article
- The gut metagenomics and metabolomics signature in patients with inflammatory bowel disease.Gut pathogens · 2022Article
- B4galnt2-mediated host glycosylation influences the susceptibility toFrontiers in microbiology · 2022Article
- The Cancer-Associated Antigens Sialyl LewisCancers · 2021Review
- Glycosyltransferase B4GALNT2 as a Predictor of Good Prognosis in Colon Cancer: Lessons from Databases.International journal of molecular sciences · 2021Article
- Mucin-Type O-Glycans: Barrier, Microbiota, and Immune Anchors in Inflammatory Bowel Disease.Journal of inflammation research · 2021Review
- Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision Medicine.Frontiers in immunology · 2020Review
- Microbe and host interaction in gastrointestinal homeostasis.Psychopharmacology · 2019Article
- MDCK-B4GalNT2 cells disclose a α2,3-sialic acid requirement for the 2009 pandemic H1N1 A/California/04/2009 and NA aid entry of A/WSN/33.Emerging microbes & infections · 2019Article
- B4GALNT2 and xenotransplantation: A newly appreciated xenogeneic antigen.Xenotransplantation · 2018Review
- Of genes and microbes: solving the intricacies in host genomes.Protein & cell · 2018Review
- A sticky end for gastrointestinal helminths; the role of the mucus barrier.Parasite immunology · 2018Review
- Predicted Bacterial Interactions AffectFrontiers in microbiology · 2018Article
- Article
- Utilization of Host-Derived Glycans by IntestinalFrontiers in microbiology · 2018Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Glycans on mucosal surfaces have an important role in host-microbe interactions. The locus encoding the blood-group-related glycosyltransferase β-1,4-N-acetylgalactosaminyltransferase 2 (B4galnt2) is subject to strong selective forces in natural house-mouse populations that contain a common allelic variant that confers loss of B4galnt2 gene expression in the gastrointestinal (GI) tract. We reasoned that altered glycan-dependent intestinal host-microbe interactions may underlie these signatures of selection. To determine whether B4galnt2 influences the intestinal microbial ecology, we profiled the microbiota of wild-type and B4galnt2-deficient siblings throughout the GI tract using 16S rRNA gene pyrosequencing. This revealed both distinct communities at different anatomic sites and significant changes in composition with respect to genotype, indicating a previously unappreciated role of B4galnt2 in host-microbial homeostasis. Among the numerous B4galnt2-dependent differences identified in the abundance of specific bacterial taxa, we unexpectedly detected a difference in the pathogenic genus, Helicobacter, suggesting Helicobacter spp. also interact with B4galnt2 glycans. In contrast to other glycosyltransferases, we found that the host intestinal B4galnt2 expression is not dependent on presence of the microbiota. Given the long-term maintenance of alleles influencing B4galnt2 expression by natural selection and the GI phenotypes presented here, we suggest that variation in B4galnt2 GI expression may alter susceptibility to GI diseases such as infectious gastroenteritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.