ArticleJournal of virology2012
Analysis of hepatitis C virus intrahost diversity across the coding region by ultradeep pyrosequencing.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Genotype- and Subtype-Independent Full-Genome Sequencing Assay for Hepatitis C Virus.Journal of clinical microbiology · 2015Trial
- Naturally occurring dominant drug resistance mutations occur infrequently in the setting of recently acquired hepatitis C.Antiviral therapy · 2015Trial
- Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin.Antimicrobial agents and chemotherapy · 2014Trial
- Dispersal of influenza virus populations within the respiratory tract shapes their evolutionary potential.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The effect of variant interference on de novo assembly for viral deep sequencing.BMC genomics · 2020Article
- Measurements of Intrahost Viral Diversity Are Extremely Sensitive to Systematic Errors in Variant Calling.Journal of virology · 2016Article
- A method for near full-length amplification and sequencing for six hepatitis C virus genotypes.BMC genomics · 2016Article
- Virologic Tools for HCV Drug Resistance Testing.Viruses · 2015Review
- Review
- Advanced molecular surveillance of hepatitis C virus.Viruses · 2015Review
- Within-host nucleotide diversity of virus populations: insights from next-generation sequencing.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Review
- ve-SEQ: Robust, unbiased enrichment for streamlined detection and whole-genome sequencing of HCV and other highly diverse pathogens.F1000Research · 2015Article
- Hepatitis C virus molecular evolution: transmission, disease progression and antiviral therapy.World journal of gastroenterology · 2014Review
- Natural reservoirs for homologs of hepatitis C virus.Emerging microbes & infections · 2014Review
- Discovery and characterization of distinct simian pegiviruses in three wild African Old World monkey species.PloS one · 2014Article
- Article
- Article
- Deep sequencing identifies two genotypes and high viral genetic diversity of human pegivirus (GB virus C) in rural Ugandan patients.The Journal of general virology · 2013Article
- V-Phaser 2: variant inference for viral populations.BMC genomics · 2013Article
- A novel hepacivirus with an unusually long and intrinsically disordered NS5A protein in a wild Old World primate.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Hepatitis C virus (HCV) is the leading cause of liver disease worldwide. In this study, we analyzed four treatment-naïve patients infected with subtype 1a and performed Roche/454 pyrosequencing across the coding region. We report the presence of low-level drug resistance mutations that would most likely have been missed using conventional sequencing methods. The approach described here is broadly applicable to studies of viral diversity and could help to improve the efficacy of direct-acting antiviral agents (DAA) in the treatment of HCV-infected patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.