ArticleJournal of virology2012
Tissue exit: a novel control point in the accumulation of antigen-specific CD8 T cells in the influenza a virus-infected lung.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Imaging leukocyte migration through afferent lymphatics.Immunological reviews · 2022Review
- Phenotypic and Immunometabolic Aspects on Stem Cell Memory and Resident Memory CD8Frontiers in immunology · 2022Review
- Arthritis flares mediated by tissue-resident memory T cells in the joint.Cell reports · 2021Article
- Review
- Afferent Lymphatic Transport and Peripheral Tissue Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues.Communications biology · 2020Article
- Formation and Maintenance of Tissue Resident Memory CD8+ T Cells after Viral Infection.Pathogens (Basel, Switzerland) · 2019Review
- Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage.The Journal of clinical investigation · 2019Article
- Anomalies in T Cell Function Are Associated With Individuals at Risk ofFrontiers in immunology · 2018Article
- Large Variations in HIV-1 Viral Load Explained by Shifting-Mosaic Metapopulation Dynamics.PLoS biology · 2016Article
- CC-chemokine receptor 7 (CCR7) deficiency alters adipose tissue leukocyte populations in mice.Physiological reports · 2016Article
- Lymphatic Vessels, Inflammation, and Immunity in Skin Cancer.Cancer discovery · 2016Review
- T Cell Trafficking through Lymphatic Vessels.Frontiers in immunology · 2016Review
- Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Molecular mechanisms of CD8(+) T cell trafficking and localization.Cellular and molecular life sciences : CMLS · 2015Review
- Mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism.PLoS computational biology · 2014Article
- CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.PloS one · 2014Article
- Location, location, location: the impact of migratory heterogeneity on T cell function.Frontiers in immunology · 2013Review
- Guarding the perimeter: protection of the mucosa by tissue-resident memory T cells.Mucosal immunology · 2013Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Memory/effector T cells efficiently migrate into extralymphoid tissues and sites of infection, providing immunosurveillance and a first line of defense against invading pathogens. Even though it is a potential means to regulate the size, quality, and duration of a tissue infiltrate, T cell egress from infected tissues is poorly understood. Using a mouse model of influenza A virus infection, we found that CD8 effector T cells egressed from the infected lung in a CCR7-dependent manner. In contrast, following antigen recognition, effector CD8 T cell egress decreased and CCR7 function was reduced in vivo and in vitro, indicating that the exit of CD8 T cells from infected tissues is tightly regulated. Our data suggest that the regulation of T cell egress is a mechanism to retain antigen-specific effectors at the site of infection to promote viral clearance, while decreasing the numbers of bystander T cells and preventing overt inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.