ArticleJournal of virology2012
Rhesus rotavirus trafficking during entry into MA104 cells is restricted to the early endosome compartment.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Structural determinants of rotavirus proteolytic activation.PLoS pathogens · 2025Article
- Specific binding sites on Rhesus rotavirus capsid protein dictate the method of endocytosis inducing the murine model of biliary atresia.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Review
- Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces.Cell host & microbe · 2022Article
- Treading a HOSTile path: Mapping the dynamic landscape of host cell-rotavirus interactions to explore novel host-directed curative dimensions.Virulence · 2021Review
- Review
- Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Most rotavirus strains require the cation-independent mannose-6-phosphate receptor, sortilin-1, and cathepsins to enter cells.Virus research · 2018Article
- Activation of PI3K, Akt, and ERK during early rotavirus infection leads to V-ATPase-dependent endosomal acidification required for uncoating.PLoS pathogens · 2018Article
- Subcellular fractionation method to study endosomal trafficking of Kaposi's sarcoma-associated herpesvirus.Cell & bioscience · 2016Article
- Rotavirus entry: a deep journey into the cell with several exits.Journal of virology · 2015Review
- Structural correlates of rotavirus cell entry.PLoS pathogens · 2014Article
- Rotaviruses reach late endosomes and require the cation-dependent mannose-6-phosphate receptor and the activity of cathepsin proteases to enter the cell.Journal of virology · 2014Article
- Genome-wide RNAi screen reveals a role for the ESCRT complex in rotavirus cell entry.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Interferon-inducible transmembrane protein 3 (IFITM3) restricts reovirus cell entry.The Journal of biological chemistry · 2013Article
- Regulation of hepatitis B virus infection by Rab5, Rab7, and the endolysosomal compartment.Journal of virology · 2013Article
- The spike protein VP4 defines the endocytic pathway used by rotavirus to enter MA104 cells.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Endocytosis has recently been implicated in rotavirus (RV) entry. We examined the role of Rabs, which regulate endosomal trafficking, during RV entry. Several structural proteins of neuraminidase-sensitive and -insensitive RVs colocalized with Rab5, an early endosome marker, but not Rab7, a late endosome marker. Dominant-negative and constitutively active mutants demonstrated that Rab5 but not Rab4 or Rab7 affects rhesus RV (RRV) infectivity. These data suggest that early RRV trafficking is confined to the early endosome compartment and requires Rab5.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.