ArticlePediatric nephrology (Berlin, Germany)2012
Effectiveness of rhGH treatment on final height of renal-transplant recipients in childhood.
Article in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Chronic Kidney Disease Interplay with Comorbidities and Carbohydrate Metabolism: A Review.Life (Basel, Switzerland) · 2023Review
- Effectiveness of growth hormone on growth and final height in paediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2022Article
- Long-Term Outcomes of Kidney Transplantation in Children.Pediatric clinics of North America · 2019Review
- Near-adult height in male kidney transplant recipients started on growth hormone treatment in late puberty.Pediatric nephrology (Berlin, Germany) · 2018Article
- Growth and Nutrition in Pediatric Chronic Kidney Disease.Frontiers in pediatrics · 2018Review
- Growth hormone therapy in children with CKD after more than two decades of practice.Pediatric nephrology (Berlin, Germany) · 2016Review
- Chronic kidney disease in children.Clinical kidney journal · 2016Article
- Growth impairment in children with pre-dialysis chronic kidney disease in Japan.Clinical and experimental nephrology · 2015Article
- Long-term outcomes of children after solid organ transplantation.Clinics (Sao Paulo, Brazil) · 2014Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowth retardation is a considerable clinical problem in children with chronic kidney disease (CKD). Optimization of metabolic and nutritional parameters does not always lead to improved growth. Recombinant human growth hormone (rhGH) treatment has been used to improve height. Several studies in the literature have shown increased growth velocity, although data on the final height (FH) reached are scarce.
aimsWe assessed the effect of rhGH on FH standard deviation score (SDS) in children with CKD following renal transplantation (RTx), comparing it with patients who did not receive rhGH (control group) but were treated with the same protocol and followed up in a single Center.
methodsThirty-three patients received rhGH treatment until FH. Fourteen who refused rhGH therapy were included in the controls. Prognostic factors for FH and changes in glomerular filtration rate (GFR) during follow-up were also analyzed
resultsFH SDS in rhGH-treated patients was significantly higher than in controls (-1.88 ± 1.14 vs -3.48 ± 1.19 SDS, respectively, p <0.05). In both groups, a similar reduction in GFR was observed. Height (SDS) at onset of rhGH treatment was the only statistically significant variable useful to predict response to treatment (p = 0.001).
conclusionOur findings confirm that rhGH is effective to improve FH in CKD RTx patients, without affecting kidney function.
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