Evidence map›Paper›PMID 22278132›Full record

ReviewStem cell reviews and reports2012

An evolving model of hematopoietic stem cell functional identity.

M William Lensch

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. The ontogeny of somatic stem cells.Stem cell reviews and reports · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

M William LenschDepartment of Pediatrics, Harvard Medical School, Harvard Stem Cell Institute, Division of Hematology/Oncology, Children's Hospital Boston, 1 Blackfan Circle, Boston, MA 02115, USA. Mathew.Lensch@childrens.harvard.edu

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Easily accessed via venipuncture, blood has been an object of study for centuries. Direct sampling of the hematopoietic tissues in the bone marrow also presents a rather low bar for biopsy acquisition from living donors, especially when compared to other systems in the body such as the heart or brain. This relatively straight-forward ability to obtain cells from the primary anatomical locations of blood cell genesis and differentiation combines with a reliable transplantation assay and well-described surface markers to make the hematopoietic stem cell (HSC) the best understood of all tissue stem cells. HSC biology has been extensively though incompletely investigated over the years. The field continually refreshes itself as new findings require us to reevaluate our understanding of hematopoiesis. After providing a brief overview of the hematopoietic system in general, this review will touch on recent findings in three areas: (1) the niche, (2) HSC migration, and (3) challenges to the "classical" model of hematopoietic ontogeny.

Indexed as

Models, BiologicalCell LineageCell MovementGenetic TherapyHematopoietic Stem CellsHumansStem Cell Niche

Identifiers

PMID22278132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.