Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Effects of a common variant in the CD38 gene on social processing in an oxytocin challenge study: possible links to autism.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Tri-Phasic Model ofOxytocin (TRIO): A systematic conceptual review of oxytocin-related ERP research.Biological psychology · 2020Pooled it
- The effect of intranasal oxytocin on neural response to facial emotions in healthy adults as measured by functional MRI: A systematic review.Psychiatry research. Neuroimaging · 2018Pooled it
- Intranasal oxytocin modulates brain responses to voice-identity recognition in typically developing individuals, but not in ASD.Translational psychiatry · 2020Trial
- Genetic modulation of oxytocin sensitivity: a pharmacogenetic approach.Translational psychiatry · 2015Trial
- Oxytocin's neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial.Molecular psychiatry · 2015Trial
- An interaction between oxytocin and a genetic variation of the oxytocin receptor modulates amygdala activity toward direct gaze: evidence from a pharmacological imaging genetics study.European archives of psychiatry and clinical neuroscience · 2013Trial
- Research Progress in Vitamin A and Autism Spectrum Disorder.Behavioural neurology · 2021Review
- CD38 is associated with communal behavior, partner perceptions, affect and relationship adjustment in romantic relationships.Scientific reports · 2020Article
- Genetics of structural and functional brain changes in autism spectrum disorder.Translational psychiatry · 2020Review
- De novo duplication on Chromosome 19 observed in nuclear family displaying neurodevelopmental disorders.Cold Spring Harbor molecular case studies · 2020Article
- A role for theThe American journal of drug and alcohol abuse · 2020Article
- Preliminary Evidence That CD38 Moderates the Association of Neuroticism on Amygdala-Subgenual Cingulate Connectivity.Frontiers in neuroscience · 2020Article
- Review
- Emerging biomarkers in autism spectrum disorder: a systematic review.Annals of translational medicine · 2019Review
- Social Interaction Improved by Oxytocin in the Subclass of Autism with Comorbid Intellectual Disabilities.Diseases (Basel, Switzerland) · 2019Review
- Social Skills Deficits in Autism Spectrum Disorder: Potential Biological Origins and Progress in Developing Therapeutic Agents.CNS drugs · 2018Review
- Emotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2.Social cognitive and affective neuroscience · 2018Article
- Sex-specific association of a common GNAS polymorphism with self-reported cognitive empathy in healthy volunteers.PloS one · 2018Article
- Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism.Molecular psychiatry · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intranasal application of oxytocin (OT) has been shown to influence behavioral and neural correlates of social processing. These effects are probably mediated by genetic variations within the OT system. One potential candidate could be the CD38 gene, which codes for a transmembrane protein engaged in OT secretion processes. A common variation in this gene (rs3796863) was recently found to be associated with autism spectrum disorders (ASD). Using an imaging genetics approach, we studied differential effects of an intranasal OT application on neural processing of social stimuli in 55 healthy young men depending on their CD38 gene variant in a double-blind placebo-controlled crossover design. Genotype had a significant influence on both behavioral and neuronal measures of social processing. Homozygotic risk allele carriers showed slower reaction times (RT) and higher activation of left fusiform gyrus during visual processing of social stimuli. Under OT activation differences between genotypes were more evident (though not statistically significantly increased) and RT were accelerated in homozygotic risk allele carriers. According to our data, rs3796863 mainly influences fusiform gyrus activation, an area which has been widely discussed in ASD research. OT seems to modulate this effect by enhancing activation differences between allele groups, which suggests an interaction between genetic makeup and OT availability on fusiform gyrus activation. These results support recent approaches to apply OT as a pharmacological treatment of ASD symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.