ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2012
Development aggravates the severity of skeletal muscle catabolism induced by endotoxemia in neonatal pigs.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Quercetin attenuates cisplatin-induced muscle atrophy via Hippo/YAP1 signaling pathway.Journal of natural medicines · 2026Article
- Impact of Prematurity on Nutrient Signaling and Protein Synthesis in Skeletal Muscle.Annual review of nutrition · 2026Review
- Investigation of Metabolites in Feces and Plasma Associated with the Number of Piglets Weaned per Sow per Year.Metabolites · 2025Article
- Cisplatin-Induced Muscle Wasting and Atrophy: Molecular Mechanism and Potential Therapeutic Interventions.Journal of cachexia, sarcopenia and muscle · 2025Review
- The Effects of Glutamine Supplementation on Liver Inflammatory Response and Protein Metabolism in Muscle of Lipopolysaccharide-Challenged Broilers.Animals : an open access journal from MDPI · 2024Article
- Embryonic Cadaverine Signaling: Implications for Plasma Free Amino Acid and Skeletal Muscle Energy Metabolism in Newly Hatched Chicks.The journal of poultry science · 2024Article
- Heat stress in pigs and broilers: role of gut dysbiosis in the impairment of the gut-liver axis and restoration of these effects by probiotics, prebiotics and synbiotics.Journal of animal science and biotechnology · 2022Review
- A narrative review of skeletal muscle atrophy in critically ill children: pathogenesis and chronic sequelae.Translational pediatrics · 2021Review
- Impact of porcine reproductive and respiratory syndrome virus on muscle metabolism of growing pigs1.Journal of animal science · 2019Article
- Regulation of Muscle Growth in Early Postnatal Life in a Swine Model.Annual review of animal biosciences · 2019Review
- The Effect of Estradiol Administration on Muscle Mass Loss and Cachexia Progression in FemaleFrontiers in endocrinology · 2019Article
- Metabolic adaptation of pigs to a Mycoplasma hyopneumoniae and Lawsonia intracellularis dual challenge.Journal of animal science · 2018Article
- Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of Nf-kapa-B p65 and translational associated signaling in the rat inferior vena cava.Data in brief · 2017Article
- Nursery pig growth performance and tissue accretion modulation due to porcine epidemic diarrhea virus or porcine deltacoronavirus challenge.Journal of animal science · 2017Article
- Insulin modulates energy and substrate sensing and protein catabolism induced by chronic peritonitis in skeletal muscle of neonatal pigs.Pediatric research · 2016Article
- Leucine supplementation stimulates protein synthesis and reduces degradation signal activation in muscle of newborn pigs during acute endotoxemia.American journal of physiology. Endocrinology and metabolism · 2016Article
- Amino acids, independent of insulin, attenuate skeletal muscle autophagy in neonatal pigs during endotoxemia.Pediatric research · 2016Article
- Novel and disruptive biological strategies for resolving gut health challenges in monogastric food animal production.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2015Review
- The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.Physiological reviews · 2015Review
- Regulation of protein degradation pathways by amino acids and insulin in skeletal muscle of neonatal pigs.Journal of animal science and biotechnology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Accretion rates of muscle protein are elevated in normal neonates, but this anabolic drive decreases with maturation. As this change occurs, it is not known whether development also influences muscle protein catabolism induced by sepsis. We hypothesize that protein degradation in skeletal muscle induced by endotoxemia becomes more severe as the neonate develops. Fasted 7- and 26-day-old pigs were infused for 8 h with LPS (0 and 10 μg·kg(-1)·h(-1)), while plasma amino acids (AA), 3-methylhistidine (3-MH), and α-actin concentrations and muscle protein degradation signal activation were determined (n = 5-7/group/age). Plasma full-length α-actin was greater in 7- than 26-day-old pigs, suggesting a higher baseline protein turnover in neonatal pigs. LPS increased plasma total AA, 3-MH, and full-length and cleaved α-actin in 26- than in 7-day-old pigs. In muscle of both age groups, LPS increased AMPK and NF-κB phosphorylation, the abundances of activated caspase 3 and E-3 ligases MuRF1 and atrogin1, as well as the abundance of cleaved α-actin, suggesting activation of muscle proteolysis by endotoxin in muscle. LPS decreased Forkhead box 01 (Fox01) and Fox04 phosphorylation and increased procaspase 3 abundance in muscle of 26-day-old pigs despite the lack of effect of LPS on PKB phosphorylation. The results suggest that skeletal muscle in healthy neonatal pigs maintains high baseline degradation signal activation that cannot be enhanced by endotoxin, but as maturation advances, the effect of LPS on muscle protein catabolism manifests its severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.