SynthesisBMC cancer2012
Diagnostic value of fine-needle aspiration biopsy for breast mass: a systematic review and meta-analysis.
Synthesis in BMC cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 97 citations in OpenAlex.
- Automated mRNA-Based Detection of ER, PR, HER2, and Ki-67 in Breast Cancer Tissue and Cytology Samples in Resource-Limited Settings.Cancer medicine · 2026Article
- Contextual Barriers and Facilitators to Implementing Ultrasound-Guided Fine-Needle Aspiration and Rapid Onsite Evaluation in a Resource-Limited Setting.JCO global oncology · 2026Article
- Age and tumor size as independent predictors of malignancy in BI-RADS 4 and 5 breast lesions: A cross-sectional study in Vietnam.PloS one · 2026Article
- Detection of Estrogen Receptor Status in Breast Cancer Cytology Samples by an Optical Nanosensor.Advanced nanobiomed research · 2025Article
- Rapid differentiation of estrogen receptor status in patient biopsy breast cancer aspirates with an optical nanosensor.bioRxiv : the preprint server for biology · 2024Article
- Development of a cost-effective compact diode-laser-based photoacoustic sensing instrument for breast tissue diagnosis.Journal of biomedical optics · 2024Article
- Rapid Onsite Evaluation for Specimen Adequacy and Triage of Breast Masses in a Low-Resource Setting.Archives of pathology & laboratory medicine · 2024Article
- [Ultrasound-Guided Intervention for Breast Lesions].Journal of the Korean Society of Radiology · 2023Review
- Breast Awareness, Self-Reported Abnormalities, and Breast Cancer in Rural Ethiopia: A Survey of 7,573 Women and Predictions of the National Burden.The oncologist · 2021Article
- Feasibility of Fine-Needle Aspiration Biopsy and Rapid On-Site Evaluation for Immediate Triage in Breast Cancer Screening in Tanzania.JCO global oncology · 2021Article
- Distribution of breast lesions diagnosed by cytology examination in symptomatic patients at Eritrean National Health Laboratory, Asmara, Eritrea: a retrospective study.BMC women's health · 2020Article
- Breast Cancer Diagnosis Using Feature Ensemble Learning Based on Stacked Sparse Autoencoders and Softmax Regression.Journal of medical systems · 2019Article
- CT-guided fine-needle aspiration biopsy of solitary pulmonary nodules under 15 mm in diameter: time for an afterthought?Journal of thoracic disease · 2019Article
- Fine-needle Aspiration Cytology to Identify a Rare Mimicker of Breast Cancer: Plasma Cell Mastitis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2018Article
- Breast Tuberculosis after Chest Trauma - a Case Report and Review of the Literature.Breast care (Basel, Switzerland) · 2016Article
- Diabetic mastopathy: imaging features and the role of image-guided biopsy in its diagnosis.Ultrasonography (Seoul, Korea) · 2016Article
- Investigation of publication bias in meta-analyses of diagnostic test accuracy: a meta-epidemiological study.BMC medical research methodology · 2014Article
- Cytological and Pathological Correlation of FNAC in Assessing Breast Lumps and Axillary Lymph Node Swellings in a Public Sector Hospital in India.Pathology research international · 2013Article
- Fine-needle aspiration cytology can play a role in neoadjuvant chemotherapy in operable breast cancer.ISRN oncology · 2013Article
- The Role of Fine Needle Aspiration Cytology in Triple Assessment of Patients with Malignant Breast Lumps.Nigerian journal of surgery : official publication of the Nigerian Surgical Research SocietyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFine-needle aspiration biopsy (FNAB) of the breast is a minimally invasive yet maximally diagnostic method. However, the clinical use of FNAB has been questioned. The purpose of our study was to establish the overall value of FNAC in the diagnosis of breast lesions.
methodsAfter a review and quality assessment of 46 studies, sensitivity, specificity and other measures of accuracy of FNAB for evaluating breast lesions were pooled using random-effects models. Summary receiver operating characteristic curves were used to summarize overall accuracy. The sensitivity and specificity for the studies data (included unsatisfactory samples) and underestimation rate of unsatisfactory samples were also calculated.
resultsThe summary estimates for FNAB in diagnosis of breast carcinoma were as follows (unsatisfactory samples was temporarily exluded): sensitivity, 0.927 (95% confidence interval [CI], 0.921 to 0.933); specificity, 0.948 (95% CI, 0.943 to 0.952); positive likelihood ratio, 25.72 (95% CI, 17.35 to 28.13); negative likelihood ratio, 0.08 (95% CI, 0.06 to 0.11); diagnostic odds ratio, 429.73 (95% CI, 241.75 to 763.87); The pooled sensitivity and specificity for 11 studies, which reported unsatisfactory samples (unsatisfactory samples was considered to be positive in this classification) were 0.920 (95% CI, 0.906 to 0.933) and 0.768 (95% CI, 0.751 to 0.784) respectively. The pooled proportion of unsatisfactory samples that were subsequently upgraded to various grade cancers was 27.5% (95% CI, 0.221 to 0.296).
conclusionsFNAB is an accurate biopsy for evaluating breast malignancy if rigorous criteria are used. With regard to unsatisfactory samples, futher invasive procedures are required in order to minimize the chance of a missed diagnosis of breast cancer.
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