ArticleReproductive biology and endocrinology : RB&E2012
Trace glucose and lipid metabolism in high androgen and high-fat diet induced polycystic ovary syndrome rats.
Article in Reproductive biology and endocrinology : RB&E, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review.Reproductive biology and endocrinology : RB&E · 2017Pooled it
- MMP-9 dysregulation and chronic inflammation in polycystic ovary syndrome: linking ovulatory dysfunction to diagnostic implications.Journal of ovarian research · 2025Article
- A combination of gliclazide and metformin attenuates obesity-induced polycystic ovary syndrome in female Wistar rats.Heliyon · 2024Article
- Impaired Carbohydrate Metabolism and Excess of Lipid Accumulation in Offspring of Hyperandrogenic Mice.Metabolites · 2022Article
- Effectiveness ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Effect of DHT-Induced Hyperandrogenism on the Pro-Inflammatory Cytokines in a Rat Model of Polycystic Ovary Morphology.Medicina (Kaunas, Lithuania) · 2020Article
- Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats.Journal of cellular and molecular medicine · 2018Article
- Effects ofImmunology, endocrine & metabolic agents in medicinal chemistry · 2018Article
- Ovary stereological features and serum biochemical factors following induction of polycystic ovary syndrome with testosterone enanthate in mice: An experimental study.International journal of reproductive biomedicine · 2018Article
- ATP synthase β-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Article
- Berberine improves glucogenesis and lipid metabolism in nonalcoholic fatty liver disease.BMC endocrine disorders · 2017Article
- Phosphatidylinositide 3-kinase inhibition: A new potential target for the treatment of polycystic ovarian syndrome.Pharmaceutical biology · 2016Article
- The Relationship between Intake of Dairy Products and Polycystic Ovary Syndrome in Women Who Referred to Isfahan University of Medical Science Clinics in 2013.International journal of preventive medicine · 2014Article
- Tracing fasting glucose fluxes with unstressed catheter approach in streptozotocin induced diabetic rats.Journal of diabetes research · 2014Article
- Castration-induced testosterone deficiency increases fasting glucose associated with hepatic and extra-hepatic insulin resistance in adult male rats.Reproductive biology and endocrinology : RB&E · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a high prevalence of diabetes mellitus (DM) and dyslipidemia in women with polycystic ovary syndrome (PCOS). The purpose of this study was to investigate the role of different metabolic pathways in the development of diabetes mellitus in high-androgen female mice fed with a high-fat diet.
methodsFemale Sprague-Dawley rats were divided into 3 groups: the control group(C), n = 10; the andronate-treated group (Andronate), n = 10 (treated with andronate, 1 mg/100 g body weight/day for 8 weeks); and the andronate-treated and high-fat diet group (Andronate+HFD), n = 10. The rate of glucose appearance (Ra of glucose), gluconeogenesis (GNG), and the rate of glycerol appearance (Ra of glycerol) were assessed with a stable isotope tracer. The serum sex hormone levels, insulin levels, glucose concentration, and the lipid profile were also measured.
resultsCompared with control group, both andronate-treated groups exhibited obesity with higher insulin concentrations (P < 0.05) but similar blood glucose concentrations. Of the two andronate-treated groups, the andronate+HFD group had the most serious insulin resistance (IR). Estrus cycles were completely acyclic, with polycystic ovaries and elevated serum lipid profiles in the andronate+HFD group (P < 0.05). Ra of glucose and GNG increased significantly in the andronate+HFD rats. However, the Ra of glycerol was similar in the three groups.
conclusionsAndronate with HFD rat model showed ovarian and metabolic features of PCOS, significant increase in glucose Ra, GNG, and lipid profiles, as well as normal blood glucose levels. Therefore, aberrant IR, increased glucose Ra, GNG, and lipid metabolism may represent the early-stage of glucose and lipid kinetics disorder, thereby might be used as potential early-stage treatment targets for PCOS.
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