ArticleBMC infectious diseases2012
TNF-α promoter polymorphism: a factor contributing to the different immunological and clinical phenotypes in Japanese encephalitis.
Article in BMC infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- Sequelae of viral CNS infections including outcomes, mechanisms, and knowledge gaps.Npj viruses · 2025Review
- Association of theViruses · 2024Article
- Potential Value of TNF-α (-376 G/A) Polymorphism and Cystatin C (CysC) in the Diagnosis of Sepsis Associated Acute Kidney Injury (S-AK I) and Prediction of Mortality in Critically Ill patients.Frontiers in molecular biosciences · 2021Article
- Assessment of tumor necrosis factor alpha polymorphism TNF-αMolecular biology reports · 2018Article
- Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis.Balkan medical journal · 2018Article
- Function of tumor necrosis factor alpha before and after mutation in gastric cancer.Saudi journal of biological sciences · 2017Article
- Significance of CCL2, CCL5 and CCR2 polymorphisms for adverse prognosis of Japanese encephalitis from an endemic population of India.Scientific reports · 2017Article
- TNF-α haplotype association with polycystic ovary syndrome - a South Indian study.Journal of assisted reproduction and genetics · 2013Article
- Novel approaches and challenges to treatment of central nervous system viral infections.Annals of neurology · 2013Review
- Tumor Necrosis Factor Alpha -308 G/A Single Nucleotide Polymorphism and Risk of Sperm Abnormalities in Iranian Males.International journal of fertility & sterilityArticle
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMore than three billion populations are living under the threat of Japanese encephalitis in South East Asian (SEA) countries including India. The pathogenesis of this disease is not clearly understood and is probably attributed to genomic variations in viral strains as well as the host genetic makeup. The present study is to determine the role of polymorphism of TNF-alpha promoter regions at positions -238G/A, -308G/A, -857C/T and -863C/A in the severity of Japanese encephalitis patients.
methodsTotal of 142 patients including 66 encephalitis case (IgM/RT-PCR positive), 16 fever cases (IgM positive) without encephalitis and 60 apparently healthy individuals (IgG positive) were included in the study. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) using site specific restriction enzymes were implemented for polymorphism study of TNF alpha promoter.
resultsFollowing the analysis of the digestion patterns of four polymorphic sites of the TNF-alpha promoter region, a significant association was observed between the allele -308A and -863C with the patients of Japanese encephalitis.
conclusionsTNF-alpha 308 G/A has been shown to be associated with elevated TNF-alpha transcriptional activity. On the other hand, polymorphism at position -863C/A in the promoter region has been reported to be associated with reduced TNF-alpha promoter activity and lower plasma TNF levels. As per the literature search, this is the first study to identify the role of TNF-alpha promoter in JE infection. Our results show that subjects with -308A and -863C alleles are more vulnerable to the severe form of JE infection.
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