ArticleEvolution; international journal of organic evolution2012
Multiple genetic pathways to similar fitness limits during viral adaptation to a new host.
Article in Evolution; international journal of organic evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Species-specific barriers restrict virus spillover potential across the Caenorhabditis genus.PLoS biology · 2026Article
- Mathematical comparison of protocols for adapting a bacteriophage to a new host.Virus evolution · 2024Article
- Modeling the Directed Evolution of Broad Host Range Phages.Antibiotics (Basel, Switzerland) · 2022Article
- Review
- Broad and Dynamic Diversification of Infectious Hepatitis C Virus in a Cell Culture Environment.Journal of virology · 2020Article
- Article
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- Article
- Genomics of Three New Bacteriophages Useful in the Biocontrol of Salmonella.Frontiers in microbiology · 2016Article
- Testing the role of genetic background in parallel evolution using the comparative experimental evolution of antibiotic resistance.Molecular biology and evolution · 2014Article
- OmpA and OmpC are critical host factors for bacteriophage Sf6 entry in Shigella.Molecular microbiology · 2014Article
- Phenotypic and genotypic convergences are influenced by historical contingency and environment in yeast.Evolution; international journal of organic evolution · 2014Article
- Lethal mutagenesis failure may augment viral adaptation.Molecular biology and evolution · 2014Article
- Evolutionarily stable attenuation by genome rearrangement in a virus.G3 (Bethesda, Md.) · 2013Article
- Genotypic but not phenotypic historical contingency revealed by viral experimental evolution.BMC evolutionary biology · 2013Article
- Viral fitness: definitions, measurement, and current insights.Current opinion in virology · 2012Review
- A cross-species view on viruses.Current opinion in virology · 2012Review
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Authors and funding
4 authors.
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Abstract
The gain in fitness during adaptation depends on the supply of beneficial mutations. Despite a good theoretical understanding of how evolution proceeds for a defined set of mutations, there is little understanding of constraints on net fitness-whether fitness will reach a limit despite ongoing selection and mutation, and if there is a limit, what determines it. Here, the dsDNA bacteriophage SP6, a virus of Salmonella, was adapted to Escherichia coli K-12. From an isolate capable of modest growth on E. coli, four lines were adapted for rapid growth by protocols differing in use of mutagen, propagation method, and duration, but using the same media, temperature, and a continual excess of the novel host. Nucleotide changes underlying those adaptations differed greatly in number and identity, but the four lines achieved similar absolute fitness at the end, an increase of more than 4000-fold phage descendants per hour. Thus, the fitness landscape allows multiple genetic paths to the same approximate fitness limit. The existence and causes of fitness limits have ramifications to genome engineering, vaccine design, and "lethal mutagenesis" treatments to cure viral infections.
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