ArticlePloS one2012
Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia.Translational psychiatry · 2022Article
- 8p21.3 deletions are rare causes of non-syndromic autism spectrum disorder.Neurogenetics · 2021Article
- Circadian rhythm disruption and mental health.Translational psychiatry · 2020Review
- Transcriptome analysis of fibroblasts from schizophrenia patients reveals differential expression of schizophrenia-related genes.Scientific reports · 2020Article
- Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice.Journal of biological rhythms · 2018Article
- Article
- Immediate Early Genes Anchor a Biological Pathway of Proteins Required for Memory Formation, Long-Term Depression and Risk for Schizophrenia.Frontiers in behavioral neuroscience · 2018Article
- The Immediate Early GeneFrontiers in behavioral neuroscience · 2018Article
- Differential expression of transcriptional regulatory units in the prefrontal cortex of patients with bipolar disorder: potential role of early growth response gene 3.Translational psychiatry · 2016Article
- Currently recognized genes for schizophrenia: High-resolution chromosome ideogram representation.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
- Htr2a Expression Responds Rapidly to Environmental Stimuli in an Egr3-Dependent Manner.ACS chemical neuroscience · 2015Article
- Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk.PloS one · 2015Article
- The reduction of volume and fiber bundle connections in the hippocampus of EGR3 transgenic schizophrenia rats.Neuropsychiatric disease and treatment · 2015Article
- Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Serial electroconvulsive Seizure alters dendritic complexity and promotes cellular proliferation in the mouse dentate gyrus; a role for Egr3.Brain stimulationArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, two genome scan meta-analysis studies have found strong evidence for the association of loci on chromosome 8p with schizophrenia. The early growth response 3 (EGR3) gene located in chromosome 8p21.3 was also found to be involved in the etiology of schizophrenia. However, subsequent studies failed to replicate this finding. To investigate the genetic role of EGR3 in Chinese patients, we genotyped four SNPs (average interval ∼2.3 kb) in the chromosome region of EGR3 in 470 Chinese schizophrenia patients and 480 healthy control subjects. The SNP rs35201266 (located in intron 1 of EGR3) showed significant differences between cases and controls in both genotype frequency distribution (P = 0.016) and allele frequency distribution (P = 0.009). Analysis of the haplotype rs35201266-rs3750192 provided significant evidence for association with schizophrenia (P = 0.0012); a significant difference was found for the common haplotype AG (P = 0.0005). Furthermore, significant associations were also found in several other two-, and three-SNP tests of haplotype analyses. The meta-analysis revealed a statistically significant association between rs35201266 and schizophrenia (P = 0.0001). In summary, our study supports the association of EGR3 with schizophrenia in our Han Chinese sample, and further functional exploration of the EGR3 gene will contribute to the molecular basis for the complex network underlying schizophrenia pathogenesis.
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