ArticleAfrican health sciences2011
Potential drug-drug interactions on in-patient medication prescriptions at Mbarara Regional Referral Hospital (MRRH) in western Uganda: prevalence, clinical importance and associated factors.
Article in African health sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Drug-drug interactions and their harmful effects in hospitalised patients: a systematic review and meta-analysis.European journal of clinical pharmacology · 2018Pooled it
- Drug-drug interaction software in clinical practice: a systematic review.European journal of clinical pharmacology · 2015Pooled it
- Risk Factors and Patterns of Drug-Drug Interactions in Two Categories of Level-3 Hospitals in Dhaka: A Cross-Sectional Study.Health science reports · 2025Article
- Article
- Prevalence and factors associated with potential drug-drug interactions in prescriptions presented at private pharmacies in Mbarara city, southwestern Uganda.BMC pharmacology & toxicology · 2024Article
- An Assessment of Medication Errors Among Pediatric Patients in Three Hospitals in Freetown Sierra Leone: Findings and Implications for a Low-Income Country.Pediatric health, medicine and therapeutics · 2024Article
- Article
- A retrospective evaluation of drug-drug interactions in patients admitted to Internal Medicine Departments in Palestinian Hospitals.SAGE open medicine · 2022Article
- Prevalence and nature of potential drug-drug interactions among hospitalized HIV patients presenting with suspected meningitis in Uganda.BMC infectious diseases · 2020Article
- Article
- Drug-Drug Interaction Associated with Mold-Active Triazoles among Hospitalized Patients.Antimicrobial agents and chemotherapy · 2016Article
- Prevalence of potential drug-drug interactions among internal medicine ward in University of Gondar Teaching Hospital, Ethiopia.Asian Pacific journal of tropical biomedicine · 2014Article
- A study of potential adverse drug-drug interactions among prescribed drugs in medicine outpatient department of a tertiary care teaching hospital.Journal of basic and clinical pharmacy · 2014Article
- Assessment of potential drug interactions among psychiatric inpatients receiving antipsychotic therapy of a secondary care hospital, United Arab Emirates.Journal of advanced pharmaceutical technology & researchArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDrug-drug interactions (DDIs) are an important cause of adverse drug reactions. The pharmacoepidemiology of such interactions in hospitals in Uganda is not known.
objectivesTo determine the prevalence, clinical importance and factors associated with potential DDIs at Mbarara Regional Referral Hospital (MRRH), western Uganda.
methodsRetrospective analysis of 235 randomly selected hospitalization episodes (medication charts and medical notes) from MRRH over a 1-year period from January to December 2008. We collected data on demographics, medications, principal diagnosis, co-morbid conditions and the length of hospital stay. Epocrates Rx® was used to identify and classify potential DDIs according to mechanism and management strategy. Descriptive statistics were generated and logistic regression used to determine associated factors.
resultsOverall prevalence of potential DDIs was approximately 23% (54 medication charts with at least one potential DDI out of 235 hospitalization episodes). Majority were postulated to occur through a pharmacodynamic mechanism (10.6%) and most required either "use with caution" (11.9%) or "modify treatment/monitor" (10.6%) as a suggested management strategy. After adjusting for confounders: age, sex, hospital department and number of co-morbid conditions, a principal diagnosis of a cardiovascular disease (OR 6.52 95% CI 1.32-32.14) and having 4 or more medicines on the chart (OR 4.30 95% CI 1.98-9.34) were associated with the presence of a potential DDI.
conclusionPotential DDIs frequently occur at MRRH although most are not clinically significant. Patients with cardiovascular diseases and those who are prescribed multiple medications need to be monitored more closely.
Indexed as
Identifiers
22275946PMC3261003W1513267202What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.